Amygdala activity is associated with the successful encoding of item, but not source, information for positive and negative stimuli
Amygdala activity is associated with the successful encoding of item, but not source, information for positive and negative stimuli
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DOI：
10.1523/jneurosci.5241-05.2006
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发表时间：
2006-03-01
影响因子：
5.3
通讯作者：
Schacter, DL
中科院分区：
文献类型：
--
作者：
Kensinger, EA;Schacter, DL
对于积极和消极信息，杏仁核活动与后续记忆之间的联系是否同样强烈，一直存在争议。此外，目前还不清楚的是，在编码过程中，杏仁核的活动是否与情绪项目呈现的所有情境方面的记忆增强相对应，还是杏仁核活动主要是增强对情绪项目本身的记忆。在目前的功能性磁共振成像研究中，参与者在执行两项任务（判断动画性或共性）中的一项时对积极和消极刺激进行编码。编码时的杏仁核活动与对积极和消极项目的后续记忆有关，但与所执行任务的后续记忆无关。杏仁核活动与中性项目的后续记忆表现没有关系。不管物品的情感内容如何，内嗅皮层的活动与对物品的后续记忆相对应，但与所执行任务的记忆不相对应，而海马体的活动与所执行任务的后续记忆相对应。这些结果首次证明，在成功编码积极和消极项目的过程中，杏仁核可以同样参与，但它的活动并不能促进编码过程中出现的所有上下文元素的编码。结果进一步表明，有时在非情绪信息中注意到的内侧颞叶的分离（即，海马体的活动导致后来对背景的记忆，内嗅皮层的活动导致后来对一个项目的记忆，但不是其背景）也适用于情绪信息。
It has been debated whether the link between amygdala activity and subsequent memory is equally strong for positive and negative information. Moreover, it has been unclear whether amygdala activity at encoding corresponds with enhanced memory for all contextual aspects of the presentation of an emotional item, or whether amygdala activity primarily enhances memory for the emotional item itself. In the present functional magnetic resonance imaging study, participants encoded positive and negative stimuli while performing one of two tasks ( judgment of animacy or commonness). Amygdala activity at encoding was related to subsequent memory for the positive and negative items but not to subsequent memory for the task performed. Amygdala activity showed no relationship to subsequent-memory performance for the neutral items. Regardless of the emotional content of the items, activity in the entorhinal cortex corresponded with subsequent memory for the item but not with memory for the task performed, whereas hippocampal activity corresponded with subsequent memory for the task performed. These results are the first to demonstrate that the amygdala can be equally engaged during the successful encoding of positive and negative items but that its activity does not facilitate the encoding of all contextual elements present during an encoding episode. The results further suggest that dissociations within the medial temporal lobe sometimes noted for non-emotional information (i.e., activity in the hippocampus proper leading to later memory for context, and activity in the entorhinal cortex leading to later memory for an item but not its context) also hold for emotional information.