HABITUATION PRODUCES FREQUENCY-SPECIFIC PLASTICITY OF RECEPTIVE-FIELDS IN THE AUDITORY-CORTEX
HABITUATION PRODUCES FREQUENCY-SPECIFIC PLASTICITY OF RECEPTIVE-FIELDS IN THE AUDITORY-CORTEX
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DOI：
10.1037/0735-7044.105.3.416
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发表时间：
1991-06-01
影响因子：
1.9
通讯作者：
WEINBERGER, NM
中科院分区：
文献类型：
--
作者：
CONDON, CD;WEINBERGER, NM
联想学习产生条件刺激(CS)-听觉皮层频率接受野（RFs）特异性可塑性；对CS频率的响应增加，而对其他频率的响应减少。本研究确定了习惯化对豚鼠（Cavia porcellus）听觉皮层神经元RF的影响。重复呈现一个频率（REP），然后重新测定RF。REP后，26/36（72%）的rf对重复频率的响应显著降低（70-75%），这是高度特异性的（带宽小于0.125倍频）。这种射频可塑性包括在REP期间反应的最初减少，但不需要在REP结束时反应减弱。潜伏期（即，在REP停止后随着时间的推移而发展）和长期频率特异性效应是明显的。因此，习惯化导致频率信息处理的特定变化，而不是反应性的普遍降低。
Associative learning produces conditioned stimulus (CS)-specific plasticity of frequency receptive fields (RFs) in the auditory cortex; responses to the CS frequency are increased, whereas responses to other frequencies are decreased. This study determined the effects of habituation on the RF of neurons in the auditory cortex of the guinea pig (Cavia porcellus). One frequency was presented repeatedly (REP) followed by redetermination of the RF. After REP, 26/36 (72%) RFs exhibited a substantial reduction (70-75%) of response to the repeated frequency, and this was highly specific (bandwidth less than 0.125 octave). This RF plasticity involves an initial decrease in response during REP but does not require attenuated responses at the end of REP. Incubation (i.e., development over time after cessation of REP) and long-term frequency-specific effects are evident. Thus, habituation induces a specific change in the processing of frequency information rather than a general reduction in responsivity.