Integrated analysis of gene expressions and metabolite features unravel immunometabolic interplay in hybrid fish (Carassius cuvieri ♀ × Carassius auratus red var ♂) infected with Aeromonas hydrophila
Integrated analysis of gene expressions and metabolite features unravel immunometabolic interplay in hybrid fish (Carassius cuvieri ♀ × Carassius auratus red var ♂) infected with Aeromonas hydrophila
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DOI：
10.1016/j.aquaculture.2022.738981
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发表时间：
2022-10
期刊：
影响因子：
4.5
通讯作者：
Ning Xiong;Zijie Fang;Xuebing Kuang;J. Ou;Sheng-Wei Luo;Shao-Jun Liu
中科院分区：
文献类型：
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作者：
Ning Xiong;Zijie Fang;Xuebing Kuang;J. Ou;Sheng-Wei Luo;Shao-Jun Liu
鱼类气单胞菌是危害鱼类生存的重要病原菌之一。本研究表明，杂交鲫（WR）接受acuteA。A.小鼠体内过氧化物酶体脂肪酸β-氧化与免疫应答之间存在一定的分子调节作用。脂质体转染可沿着肾脏中免疫、凋亡和代谢相关基因表达的显著改变而减轻抗氧化状态，而大部分差异代谢物（DM）富含类固醇衍生物和磷脂。此外，甲羟戊酸（MVA）途径和磷脂水解被确定为在WR后的关键细胞过程。挑战。这些结果可能提供了一个深入了解免疫代谢策略，对A。传染病。
Aeromonas hydrophilais one of important pathogenic bacteria that can imperil fish survival. Current study suggested that hybrid crucian carp (WR) receiving acuteA. hydrophilachallenge exerted a molecular regulation linking peroxisomal fatty acid β-oxidation to immune response.A. hydrophilainfection may alleviate antioxidant status along with the significant alternation of immune-, apoptosis- and metabolic-related gene expressions in kidney, whereas most portions of differential metabolites (DMs) were enriched in steroid derivatives and phospholipids. In addition, mevalonate (MVA) pathway and phospholipid hydrolysis were identified as crucial cellular processes in WR afterA. hydrophilachallenge. These results may provide an insight into immunometabolic strategy againstA. hydrophilainfection.