Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide.
Blood Vessels and Perivascular Phagocytes of Prefrontal White and Gray Matter in Suicide.
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自杀时前额叶白质和灰质的血管和血管周围吞噬细胞。
DOI：
10.1093/jnen/nly103
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发表时间：
2019
影响因子：
3.2
通讯作者：
Dwork,AndrewJ
中科院分区：
文献类型：
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作者：
Schnieder,TatianaP;ZhouQin,IsaiahD;Trencevska-Ivanovska,Iskra;Rosoklija,Gorazd;Stankov,Aleksandar;Pavlovski,Goran;Mann,JJohn;Dwork,AndrewJ
炎症过程可能导致精神疾病和自杀。早些时候，我们报道了自杀死亡者背前额叶白色物质（DPFWM）中血管周围吞噬细胞的密度高于非自杀死亡者。为了区分更大的血管分布和血管周围吞噬细胞对血管的更大覆盖，并确定过量的血管周围吞噬细胞是来自小胶质细胞还是来自非实质免疫细胞，我们通过葡萄糖转运蛋白Glut-1染色对血管表面积密度（AVTOTAL）进行体视学估计，以及背侧和腹侧前额叶白色和灰质中CD 163免疫反应（IR）的血管表面积（AF）分数（CD 163 AF）。在任何地区，死亡方式或精神病诊断均与CD 163 AF无关。与非自杀者相比，DPFWM中自杀与较低的AVTOTAL相关（p = 0.018），但与其他3个感兴趣区域的AVTOTAL无关。因此，早期观察到自杀后DPFWM中血管周围吞噬细胞密度增加不能归因于外周单核细胞浸润或血管分布增加。腹侧AVTOTAL大于背侧（p = 0.002）是自杀和白色物质所特有的。
Inflammatory processes may contribute to psychiatric disorders and suicide. Earlier, we reported greater densities of perivascular phagocytes in dorsal prefrontal white matter (DPFWM) in suicide than in non-suicide deaths. To distinguish between greater vascularity and greater coverage of vessels by perivascular phagocytes, and to determine whether the excess of perivascular phagocytes is derived from microglia or from non-parenchymal immune cells, we made stereological estimates of vascular surface area density (AVTOTAL) by staining for glucose transporter Glut-1, and the fraction of vascular surface area (AF) immunoreactive (IR) for CD163 (CD163 AF) in dorsal and ventral prefrontal white and gray matter. Manner of death or psychiatric diagnosis showed no association with CD163 AF in any region. Suicide was associated with a lower AVTOTALcompared with non-suicides in DPFWM (p = 0.018) but not with AVTOTALin the 3 other regions of interest. Thus, the earlier observation of increased density of perivascular phagocytes in DPFWM after suicide cannot be attributed to infiltration by peripheral monocytes or to increased vascularity. Greater AVTOTALventrally than dorsally (p = 0.002) was unique to suicide and white matter.