Firing behavior of vestibular neurons during active and passive head movements: Vestibulo-spinal and other non-eye-movement related neurons
Firing behavior of vestibular neurons during active and passive head movements: Vestibulo-spinal and other non-eye-movement related neurons
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DOI：
10.1152/jn.1999.82.1.416
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发表时间：
1999-07-01
影响因子：
2.5
通讯作者：
Belton, T
中科院分区：
文献类型：
--
作者：
McCrea, RA;Gdowski, GT;Belton, T
在3只头部在水平半规管平面自由运动的松鼠身上，研究了51个对被动头部旋转敏感的非眼动相关前庭中枢神经元的放电行为。在自发眼跳中，单位对主动头部运动的敏感度与对被动头部旋转的敏感度进行了比较。电刺激同侧前庭神经后，大多数单位(29/35)在单突触潜伏期被激活。其中9个是前庭-脊髓单位，它们是在电刺激脊髓的腹内侧束后反向激活的。所有单位对主动头部运动的敏感度都低于对被动全身旋转的敏感度。在大多数细胞(37/51，73%)中，包括所有9个已识别的前庭-脊髓单位，与主动头部运动相关的前庭信号被取消。其余单位(n=14，27%)对主动头部运动反应敏感，但反应减弱20%-75%。大多数单位对被动的头对躯干旋转和对全身旋转几乎同样敏感；这表明与主动头部运动相关的前庭信号主要是通过减去头部运动传出复制信号来抵消的。在眼跳过程中，大多数单位对被动全身旋转的敏感度没有变化。感觉加工的一个基本特征是区分自我产生的和外部诱导的感觉事件的能力。我们的观察表明，这种区别是在前庭系统处理的早期阶段做出的。
The firing behavior of 51 non-eye movement related central vestibular neurons that were sensitive to passive head rotation in the plane of the horizontal semicircular canal was studied in three squirrel monkeys whose heads were free to move in the horizontal plane. Unit sensitivity to active head movements during spontaneous gaze saccades was compared with sensitivity to passive head rotation. Most units (29/35 tested) were activated at monosynaptic latencies following electrical stimulation of the ipsilateral vestibular nerve. Nine were vestibulo-spinal units that were antidromically activated following electrical stimulation of the ventromedial funiculi of the spinal cord at C1. All of the units were less sensitive to active head movements than to passive whole body rotation. In the majority of cells (37/51, 73%), including all nine identified vestibule-spinal units, the vestibular signals related to active head movements were canceled. The remaining units (n = 14, 27%) were sensitive to active head movements, but their responses were attenuated by 20-75%. Most units were nearly as sensitive to passive head-on-trunk rotation as they were to whole body rotation; this suggests that vestibular signals related to active head movements were cancelled primarily by subtraction of a head movement efference copy signal. The sensitivity of most units to passive whole body rotation was unchanged during gaze saccades. A fundamental feature of sensory processing is the ability to distinguish between self-generated and externally induced sensory events. Our observations suggest that the distinction is made at an early stage of processing in the vestibular system.