Comparative analysis of the maternal and umbilical interleukin-8 levels in normal pregnancies and in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation
Comparative analysis of the maternal and umbilical interleukin-8 levels in normal pregnancies and in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation
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DOI：
10.1080/14767050701412719
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发表时间：
2007-07-01
影响因子：
1.8
通讯作者：
Oleszczuk, Jan
中科院分区：
文献类型：
--
作者：
Laskowska, Marzena;Laskowska, Katarzyna;Oleszczuk, Jan
目标。本研究的目的是测定伴有宫内正常生长和宫内生长迟缓（IUGR）的子痫前期妊娠和正常妊娠的孕妇和脐带血清中白细胞介素-8 （IL-8）的水平。患者和方法。本研究选取15例与胎龄体重儿相适应的单胎妊娠合并先兆子痫患者和12例妊娠合并IUGR的先兆子痫患者。对照组为10例健康、血压正常的单胎无并发症妊娠患者。采用ELISA法测定母血和脐血IL-8浓度。两组患者资料无统计学差异。研究组的收缩压、舒张压和平均动脉压均高于对照组。子痫前期合并IUGR组新生儿出生体重和胎龄均较低。与对照组相比，两个子痫前期患者组均发现母体和脐带血清IL-8水平升高。各组患者脐带血IL-8浓度均有高于母体血的趋势。这些较高的IL-8浓度可能与细胞凋亡、炎症、中性粒细胞活化、内皮细胞损伤和功能障碍以及内皮通透性增加有关。它们也可能参与补偿不平衡的细胞凋亡和血管阻力的尝试。我们的研究结果提示IL-8可能在子痫前期的发病机制和后遗症中起重要作用，特别是在子痫前期妊娠合并IUGR中。
Objectives. The aim of this study was to determine the maternal and umbilical cord serum levels of interleukin-8 (IL-8) in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation (IUGR), and in normotensive pregnancies.Patients and methods. The study was carried out on 15 patients with singleton pregnancies complicated by preeclampsia with appropriate for gestational age weight infants and 12 pregnant patients with preeclampsia complicated by IUGR. The control group consisted of 10 healthy normotensive delivering patients with singleton uncomplicated pregnancies. Maternal and umbilical serum IL-8 concentrations were estimated using the ELISA method.Results. There were no statistically significant differences in patient profiles between the groups. Systolic and diastolic blood pressure and mean arterial blood pressure were higher in the study groups in comparison with the control group. Lower birth weight and lower gestational age at birth were observed in the group of patients with preeclampsia complicated by IUGR. Increased maternal and umbilical serum levels of IL-8 were found in both preeclamptic patient groups in comparison with the control group. The umbilical cord blood concentrations of IL-8 in all groups of patients tended to be higher in comparison with the maternal blood.Conclusions. It seems that these higher IL-8 concentrations may be associated with apoptosis, inflammation, neutrophil activation, endothelial cell damage and dysfunction, and increased endothelial permeability. They may also participate in an attempt to compensate for the imbalanced apoptosis and vascular resistance. Our findings suggest a possible significant role of IL-8 in the pathogenesis and sequelae of preeclampsia, especially in preeclamptic pregnancies complicated by IUGR.