Automated Morphometry of the Visual Pathway in Primary Open-Angle Glaucoma
Automated Morphometry of the Visual Pathway in Primary Open-Angle Glaucoma
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DOI：
10.1167/iovs.10-5682
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发表时间：
2011-04-01
影响因子：
4.4
通讯作者：
Cornelissen, Frans W.
中科院分区：
文献类型：
--
作者：
Hernowo, Aditya T.;Boucard, Christine C.;Cornelissen, Frans W.
目的。目的：探讨原发性开角型青光眼（POAG）是否与眼与视觉皮层间视通路结构体积变化有关。为了回答这个问题，磁共振成像（MRI）与自动分割和基于体素的形态测量（VBM）相结合。8例POAG患者和12例年龄匹配的对照组参加了研究。只有伴有双侧青光眼视野丧失的POAG患者被纳入研究。双眼的暗斑必须包括中心旁区域，并且至少部分重叠。所有参与者都进行了高分辨率，T(1)加权，3-T MRI扫描[b]。随后，用VBM测定视神经、视交叉、视束、外侧膝状核（LGN）和视神经辐射的体积。采用协方差分析比较POAG组和对照组的这些体积。测量的主要结果参数为视通路结构的体积。与对照组相比，青光眼患者视觉通路上的所有结构，包括视神经、视交叉、视束、LGN和视辐射的体积均减小（P < 0.005）。POAG对整个视觉通路（从视神经到视辐射）的结构产生不利影响。此外，MRI与自动形态测量相结合可用于帮助检测和评估青光眼脑损伤。（Invest Ophthalmol Vis Sci. 2011;52:2758-2766） DOI:10.1167/iovs.10-5682
PURPOSE. To establish whether primary open-angle glaucoma (POAG) is associated with a change in volume of the visual pathway structures between the eyes and the visual cortex.METHODS. To answer this question, magnetic resonance imaging (MRI) was used in combination with automated segmentation and voxel-based morphometry (VBM). Eight patients with POAG and 12 age-matched control subjects participated in the study. Only POAG patients with bilateral glaucomatous visual field loss were admitted to the study. The scotoma in both eyes had to include the paracentral region and had to, at least partially, overlap. All participants underwent high-resolution, T(1)-weighted, 3-T MRI scanning[b]. Subsequently, VBM was used to determine the volume of the optic nerves, the optic chiasm, the optic tracts, the lateral geniculate nuclei (LGN), and the optic radiations. Analysis of covariance was used to compare these volumes in the POAG and control groups. The main outcome parameter of the measurement was the volume of visual pathway structures.RESULTS. Compared with the controls, subjects with glaucoma showed reduced volume (P < 0.005) of all structures along the visual pathway, including the optic nerves, the optic chiasm, the optic tracts, the LGN, and the optic radiations.CONCLUSIONS. POAG adversely affects structures along the full visual pathway, from the optic nerve to the optic radiation. Moreover, MRI in combination with automated morphometry can be used to aid the detection and assessment of glaucomatous damage in the brain. (Invest Ophthalmol Vis Sci. 2011;52:2758-2766) DOI:10.1167/iovs.10-5682