Lithium antagonizes ethanol intoxication in alcoholics.
Lithium antagonizes ethanol intoxication in alcoholics.
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锂可以拮抗酗酒者的乙醇中毒。
DOI：
10.1176/ajp.141.12.1517
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Huey,LY
中科院分区：
文献类型：
--
作者：
Judd,LL;Huey,LY
在一项安慰剂对照的双盲研究中，35名服用锂的戒毒酒精患者报告称，当受到标准剂量的乙醇挑战时，醉酒较少，继续饮酒的欲望下降，认知功能障碍也较少。锂似乎也能对抗酒精导致的认知和知觉运动能力的下降。当酗酒者被诊断为情感障碍和没有情感障碍时，没有注意到锂效应的差异。作者认为，除了情绪正常化外，锂直接影响酒精中毒的能力可能有助于解释其在酒精中毒中的潜在治疗效果，为锂可能在治疗酒精中毒中有用提供了进一步的确凿证据。
Thirty-five detoxified alcoholics given lithium in a placebo-controlled, double-blind study reported less intoxication, a decrease in the desire to continue drinking, and less cognitive dysfunction when challenged by standardized doses of ethanol. Lithium also appeared to antagonize the ethanol-induced decrement in cognitive and perceptual motor performance. No differential lithium effect was noted when alcoholics were divided by diagnoses of affective disorder versus no affective disorder. The authors suggest that, in addition to mood normalization, lithium's capacity to directly affect ethanol intoxication may help explain its potential therapeutic efficacy in alcoholism, providing further confirmatory evidence that lithium may be useful in the treatment of alcoholism.