Neuromedin S: discovery and functions.
Neuromedin S: discovery and functions.
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DOI：
10.1007/400_2007_054
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发表时间：
2008
影响因子：
--
通讯作者：
K. Mori;M. Miyazato;K. Kangawa
中科院分区：
文献类型：
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作者：
K. Mori;M. Miyazato;K. Kangawa
Neuromedin S是一种新的神经肽，由36个氨基酸组成， 孤儿G蛋白偶联受体FM-3/GPR 66和FM-4/TGR-1的内源性配体，经鉴定 迄今为止分别为1型和2型神经介肽U（NMU）受体。该肽被命名为 神经介肽S（NMS），因为它特异性表达于下丘脑的视交叉上核。 NMS在结构上与NMU相关;这些肽共享C-末端核心结构。在本审查中， 我们将概述最近发现的结构，同源受体，分布，和可能的 NMS的生理功能。
Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively. The peptide was designated neuromedin S (NMS) because it is specifically expressed in the suprachiasmatic nucleus of the hypothalamus. NMS is structurally related to NMU; these peptides share a C-terminal core structure. In this review, we will outline the recent discoveries regarding the structure, cognate receptors, distribution, and possible physiological functions of NMS.