Role of glandular kallikreins as growth factor processing enzymes: Structural and evolutionary considerations
Role of glandular kallikreins as growth factor processing enzymes: Structural and evolutionary considerations
复制标题
DOI：
10.1002/jcb.240330107
复制
发表时间：
1987-01
影响因子：
4
通讯作者：
P. J. Isackson;J. Dunbar;R. Bradshaw
中科院分区：
文献类型：
--
作者：
P. J. Isackson;J. Dunbar;R. Bradshaw
激素和生长因子通常通过有限的蛋白水解从较大的前体释放。病原体在位置和性质方面仍不明确。蛋白酶的一个子集，腺激肽释放酶，在少数情况下，部分是因为它们与某些激素的成熟形式的特定关联。然而，在某些物种中有限的分布和低拷贝数使人们对这一假设产生了怀疑，它们可能发挥其他生理功能，仍有待阐明。
Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association with mature forms of some hormones. However, limited distribution and low copy number in some species cast doubt on this hypothesis, and they may well play other physiological functions that remain to be elucidated.