Microparticles and pregnancy complications
Microparticles and pregnancy complications
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DOI：
10.1016/s0049-3848(11)70019-6
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发表时间：
2011-02-01
影响因子：
7.5
通讯作者：
Brenner, Benjamin
中科院分区：
文献类型：
--
作者：
Aharon, Anat;Brenner, Benjamin
微粒（MP）从各种细胞的细胞膜脱落，促进血栓形成，介导促炎作用，并可能导致内皮功能障碍。正常妊娠的特征是MP水平高于非妊娠健康妇女，但其发病率、细胞来源和在妊娠相关并发症中的作用仍存在争议。正常妊娠是一种获得性高凝状态，是由于促凝血剂增加和天然抗凝剂减少所致。妊娠相关的并发症，如先兆子痫，宫内胎儿生长受限（IUGR）和胎儿丢失与胎盘功能障碍，并可能导致显着的孕产妇和胎儿的发病率和mortals.This文章突出的作用，在母体胎盘串扰和微粒，血栓形成和妊娠并发症之间的相互作用。(C)2011爱思唯尔有限公司版权所有。
Microparticles (MPs) are shed from cell membranes of a variety of cells, promote thrombus formation, mediate pro-inflammatory effects and may cause endothelial dysfunction. Normal pregnancy is characterized by increased levels of MPs compared to non-pregnant healthy women but the prevalence, cell origin and the role of MPs in pregnancy-related complications remain controversial.Normal pregnancy is an acquired hyper-coagulable state due to an increase in procoagulants and decrease in natural anticoagulants. Pregnancy-related complications such as preeclampsia, intrauterine fetal growth restriction (IUGR) and fetal loss are associated with placental dysfunction and may cause significant maternal and fetal morbidity and mortality.This article highlights the role of microparticles in maternal placental crosstalk and the interplay between microparticles, thrombosis and pregnancy complications. (C) 2011 Elsevier Ltd. All rights reserved.