Bidirectional short-term plasticity during single-trial learning of cerebellar-driven eyelid movements in mice.
Bidirectional short-term plasticity during single-trial learning of cerebellar-driven eyelid movements in mice.
复制标题
小鼠小脑驱动的眼睑运动的单次试验学习期间的双向短期可塑性。
DOI：
10.1016/j.nlm.2019.107097
复制
发表时间：
2020
影响因子：
2.7
通讯作者：
Medina,JavierF
中科院分区：
文献类型：
--
作者：
Najafi,Farzaneh;Medina,JavierF
大脑不断地监测自己的表现，利用错误信号触发可塑性机制，帮助改善未来的行为。事实上，在许多学习任务中，包括小脑依赖性眨眼条件反射，在一次错误试验后，已经观察到行为的适应性变化。在这里，我们证明了小鼠眨眼条件反射过程中单次尝试学习的可塑性受到正负预测错误的双向调节，对行为具有短暂的影响（在<1分钟内衰减），并且可以在没有错误的情况下触发。我们认为，这三个属性的单次试验学习可能是特别有用的驱动机制的运动适应，可以实现最佳性能，在面对环境干扰的快速时标。
The brain is constantly monitoring its own performance, using error signals to trigger mechanisms of plasticity that help improve future behavior. Indeed, adaptive changes in behavior have been observed after a single error trial in many learning tasks, including cerebellum-dependent eyeblink conditioning. Here, we demonstrate that the plasticity underlying single-trial learning during eyeblink conditioning in mice is bidirectionally regulated by positive and negative prediction errors, has an ephemeral effect on behavior (decays in <1 min), and can be triggered in the absence of errors in performance. We suggest that these three properties of single-trial learning may be particularly useful for driving mechanisms of motor adaptation that can achieve optimal performance in the face of environmental disturbances with a fast timescale.