Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study
Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study
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DOI：
10.1016/j.rmed.2009.08.013
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发表时间：
2010-02-01
影响因子：
4.3
通讯作者：
Selman, Moises
中科院分区：
文献类型：
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作者：
Garcia-Sancho Figueroa, Ma. Cecilia;Carrillo, Guillermo;Selman, Moises
特发性肺纤维化（IPF）的病因仍然知之甚少，但一些研究表明吸烟或其他职业或环境暴露、糖尿病或胃食管反流可能起作用。在本研究中，我们评价了一组97例连续IPF患者和560例患有5种不同呼吸系统疾病的患者的临床记录，这些患者作为对照进行检查：哮喘（n = 111）、慢性阻塞性肺疾病（n = 132）、鳞状细胞癌。肺癌（n = 118）、肺腺癌（n = 101）和有耳鼻咽喉科问题但无肺部疾病的患者（n = 98）。在双变量分析中，配偶性别、糖尿病和既往吸烟者与IPF相关。经这些变量调整后，多变量分析显示2型糖尿病[IPF患者11.3% vs对照组2.9%，OR = 4.3（95% CI：1.9-9.8），p < 0.0001]是IPF相关的独立风险因素。我们的研究结果为DM 2和特发性肺纤维化之间的假定关系提供了额外的证据。实验研究是必要的，以彻底评估参与这种关联的致病机制。(C)2009爱思唯尔有限公司保留所有权利。
The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma (n = 111), chronic obstructive pulmonary disease (n = 132), squamous cell. lung carcinoma (n = 118), lung adenocarcinoma (n = 101) and patients with otorhinolaryngology problems but without lung disease (n = 98). In bivariate analyses mate sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR = 4.3 (95% CI: 1.9-9.8), p < 0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association. (C) 2009 Elsevier Ltd. All rights reserved.