Functions for proteinases in the ovulatory process
Functions for proteinases in the ovulatory process
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DOI：
10.1016/j.bbapap.2005.05.002
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发表时间：
2005-08-01
影响因子：
3.2
通讯作者：
Takahashi, T
中科院分区：
文献类型：
--
作者：
Ohnishi, J;Ohnishi, E;Takahashi, T
卵巢是一个独特的、动态的器官，在女性生殖活动中，它的组织发育和重塑程度迅速而广泛。排卵是一个定向和顺序的过程，伴随着广谱蛋白水解，最终在卵泡破裂释放成熟的卵母细胞。本文将重点介绍六种参与排卵过程各方面的代表性蛋白酶的潜在作用：基质金属蛋白酶（MMPs），纤溶酶原激活物(PA)/纤溶酶，溶酶素和金属蛋白酶结构域与血小板反应蛋白基序（ADAMTS），组织蛋白酶- l，妊娠相关血浆蛋白-a （ppp -a）和骨形态发生蛋白1/哺乳动物粪便蛋白（BMP-1/mTld）。基于对表达和功能的研究，这些选定的蛋白酶提供并共享多种功能，从切割细胞外基质（ECM）的成分到调节非ECM分子，如各种生长因子及其结合蛋白。在小鼠中，每个基因的基因缺失一致地显示出它们在生殖活动中的功能重叠。(c) 2005 Elsevier B.V.版权所有
The ovary is a unique and dynamic organ in respect to rapid and extensive degrees of tissue development and remodeling that are periodically repeated in the female reproductive activity. Ovulation is a directed and sequential process accompanied by broad-spectrum proteolysis and culminates in the follicular rupture to release the matured oocyte. This review will focus on the potential roles of six representative proteinases that are involved in various aspects of ovulatory processes: matrix metalloproteinases (MMPs), plasminogen activator (PA)/plasmin, a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS), cathepsin-L, pregnancy-associated plasma protein-A (PAPP-A), and bone morphogenetic protein 1/mammalian Tolloid (BMP-1/mTld). Based on the studies of expression and function, these selected proteinases provide and share diverse functions ranging from cleaving components of the extracellular matrix (ECM) to modulating non-ECM molecules, such as various growth factors and their binding proteins. Consistently, the genetic deletion of each individual gene in mice shows their functional overlap in the reproductive activity. (c) 2005 Elsevier B.V. All rights reserved.