Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity:: Results of a prospective multicenter study of 166 patients
Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity:: Results of a prospective multicenter study of 166 patients
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DOI：
10.1016/j.ijrobp.2006.08.055
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发表时间：
2007-01-01
影响因子：
7
通讯作者：
Poetter, Rochard
中科院分区：
文献类型：
--
作者：
Goldner, Gregor;Tomicek, Birgit;Poetter, Rochard
目的：评估维也纳直肠镜检查评分（VRS）作为检测和分类前列腺癌放疗（RT）后直肠粘膜病理变化的可行且有效的工具，并将其结果与欧洲癌症研究和治疗组织（EORTC）/放射治疗肿瘤学组（RTOG）晚期直肠毒性评分相关联。方法和材料：在德国-德国前瞻性多中心试验中，共有486例局限性前列腺癌患者接受了高达70或74戈伊的外射束RT。在166例患者中，自愿直肠乙状结肠镜检查前和12个月和/或24个月后RT。病理结果，如毛细血管扩张，充血的粘膜，溃疡分级（0-3级），并根据VRS总结。记录晚期直肠副作用（EORTC/RTOG），并与相应的VRS.Results相关：RT前，99%的VRS评分为0。中位随访时间为40个月。总体而言，EORTC/RTOG检测到43%的晚期直肠副作用等级或评分1-3，而VRS检测到68%（p < 0.05）。使用EORTC/RTOG发现的0、1、2和3级晚期直肠副作用分别为57%、11%、28%和3%; VRS为0、1、2和3时相应的百分比分别为32%、22%、32%和14%。VRS与EORTC/RTOG之间存在显著的一致性（p < 0.01）。结论：VRS是一种可行的、有效的工具，可用于多中心研究中描述和分类RT后直肠粘膜的病理改变。VRS和EORTC/RTOG显示出高度的一致性。然而，VRS明显更敏感。(c)2007爱思唯尔公司
Purpose: To evaluate the Vienna Rectoscopy Score (VRS) as a feasible and effective tool for detecting and classifying pathologic changes in the rectal mucosa after radiotherapy (RT) for prostate cancer, and, also, to correlate its findings with the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) score for late rectal toxicity.Methods and Materials: A total of 486 patients with localized prostate cancer underwent external-beam RT up to 70 or 74 Gy within an Austrian-German prospective multicenter trial. In 166 patients, voluntary rectal sigmoidoscopy was performed before and at 12 and/or 24 months after RT. Pathologic findings such as telangiectasia, congested mucosa, and ulcers were graded (Grades 0-3) and summarized according to the VRS. Late rectal side effects (EORTC/RTOG) were documented and correlated with the corresponding VRS.Results: Before RT, 99% had a VRS score of 0. The median follow-up was 40 months. Overall, a late rectal side effects grade or score 1-3 was detected in 43% by EORTC/RTOG compared with 68% by VRS (p < 0.05). Grades 0, 1, 2, and 3 late rectal side effects were found using EORTC/RTOG in 57%, 11%, 28%, and 3%, respectively; the corresponding percentages were 32%, 22%, 32%, and 14% for a VRS of 0, 1, 2, and 3, respectively. A significant coherence between the VRS and EORTC/RTOG was found (p < 0.01).Conclusions: The VRS is a feasible and effective tool for describing and classifying pathologic findings in the rectal mucosa after RT within a multicenter trial. The VRS and EORTC/RTOG showed a high coherence. However the VRS was significantly more sensitive. (c) 2007 Elsevier Inc.