Biological properties and functional determinants of the urotensin II receptor
Biological properties and functional determinants of the urotensin II receptor
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DOI：
10.1016/j.peptides.2007.10.027
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发表时间：
2008-05-01
期刊：
影响因子：
3
通讯作者：
Leduc, Richard
中科院分区：
文献类型：
--
作者：
Proulx, Christophe D.;Holleran, Brian J.;Leduc, Richard
尾加压素II受体（UT）是G蛋白偶联受体（GPCR）家族的成员，并结合环十一肽尾加压素II（U-II）以及八肽尾加压素II相关肽（URP）。活性UT通过多种信号转导途径介导多效性效应，包括与G蛋白偶联和激活丝裂原活化蛋白激酶途径。在UT中发现了对活性重要的A类GPCR的几个高度保守的残基和基序。这篇综述强调了一些推定的作用，这些图案的结合，激活和脱敏的UT。(c)2007年爱思唯尔公司All rights reserved.
The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT. (c) 2007 Elsevier Inc. All rights reserved.