Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex
Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex
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DOI：
10.1016/s0165-5728(99)00044-2
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发表时间：
1999-06-01
影响因子：
3.3
通讯作者：
Nottet, HSLM
中科院分区：
文献类型：
--
作者：
Boven, LA;Middel, J;Nottet, HSLM
虽然神经营养因子目前被认为是治疗神经退行性疾病的方法，但对于它们在病理条件下是否存在于中枢神经系统仍知之甚少。我们研究了神经营养分子NGF、bFGF、BDNF和IGF-1在AIDS痴呆患者脑组织中的表达。与IGF-1和BDNF相比，NGF和bFGFm RNA水平显著升高。NGF免疫反应在血管周围呈强阳性反应，并与浸润性巨噬细胞共存，而bFGF在具有星形细胞形态特征的细胞中呈强阳性表达。这些数据表明，单独诱导神经生长因子和碱性成纤维细胞生长因子似乎不足以作为预防ADC的代偿机制。(C)1999 Elsevier Science B.V.保留所有权利。
Although neurotrophic factors are currently considered as treatment for neurodegenerative diseases, little is still known about their presence in the central nervous system under pathological conditions. We investigated the expression of the neurotrophic molecules NGF, bFGF, BDNF and IGF-1 in brain tissue of patients suffering from AIDS dementia complex. In contrast to IGF-1 and BDNF, NGF and bFGF mRNA levels were significantly elevated. Strong NGF immunoreactivity was found in perivascular areas and was colocalized with infiltrating macrophages, whereas intense bFGF staining was found in cells with characteristic astrocytic morphology. These data suggest that the induction of NGF and bFGF alone appears to be insufficient as a compensatory mechanism to prevent ADC. (C) 1999 Elsevier Science B.V. All rights reserved.