Acute liver failure:: A critical appraisal of available animal models
Acute liver failure:: A critical appraisal of available animal models
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DOI：
10.1007/s11011-005-7927-z
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发表时间：
2005-12-01
影响因子：
3.6
通讯作者：
Butterworth, RF
中科院分区：
文献类型：
--
作者：
Bélanger, M;Butterworth, RF
充分的急性肝衰竭（ALF）实验模型的可用性是最重要的，以提供更好地了解这种情况，并允许开发和测试新的治疗方法与ALF患者。然而，ALF的众多病因和并发症导致了这种情况的复杂性，并使ALF的理想实验模型的开发比预期的更困难。相反，一些不同的模型，可用于研究ALF的具体方面已经开发出来。用于在实验动物中诱导ALF的最常见方法是外科手术、毒性肝损伤或两者的组合。尽管病毒性肝炎在世界范围内的高患病率，但很少有令人满意的ALF病毒模型。已建立和新开发的模型ALF的审查。
The availability of adequate experimental models of acute liver failure (ALF) is of prime importance to provide a better understanding of this condition and allow the development and testing of new therapeutic approaches for patients with ALF. However, the numerous etiologies and complications of ALF contribute to the complexity of this condition and render the development of an ideal experimental model of ALF more difficult than expected. Instead, a number of different models that may be used for the study of specific aspects of ALF have been developed. The most common approaches used to induce ALFin experimental animals are surgical procedures, toxic liver injury,or a combination of both. Despite the high prevalence of viral hepatitis worldwide, very few satisfactory viral models of ALF are available. Established and newly developed models of ALF are reviewed.