Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer.

Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer.
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发表时间：
2003-11
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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通讯作者：
F. Esteva;A. Sahin;G. Rassidakis;L. Yuan;T. Smith;Ying Yang;M. Gilcrease;M. Cristofanilli;R. Nahta;L. Pusztai;F. Claret
F. Esteva;A. Sahin;G. Rassidakis;L. Yuan;T. Smith;Ying Yang;M. Gilcrease;M. Cristofanilli;R. Nahta;L. Pusztai;F. Claret
中科院分区：
其他
文献类型：
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作者：
F. Esteva;A. Sahin;G. Rassidakis;L. Yuan;T. Smith;Ying Yang;M. Gilcrease;M. Cristofanilli;R. Nahta;L. Pusztai;F. Claret

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目的研究Jun激活域结合蛋白1(JAB1)在乳腺癌组织和癌旁正常组织中的表达水平，探讨JAB1与p27(Kip1)在浸润性乳腺癌中的表达是否存在相关性，并探讨JAB1和p27(Kip1)在无淋巴结转移乳腺癌中的预后意义。实验设计：采用免疫印迹法检测10对乳腺浸润性肿瘤组织和邻近正常组织中JAB1的水平。我们还研究了220例未接受辅助系统治疗的淋巴结阴性乳腺癌患者石蜡包埋组织标本中JAB1和p27(Kip1)的免疫反应性。中位随访期为15年。结果JAB1在浸润性肿瘤中的表达高于癌旁正常组织(P=0.01)。在57%的浸润性乳腺癌中观察到JAB1过表达。P27(Kip1)在70%的肿瘤标本中呈低表达。JAB1和p27(Kip1)的表达水平呈负相关(P=0.01)。JAB1过表达与患者年龄>50岁(P=0.03)和肿瘤大小<2 cm(P=0.01)有关。P27(Kip1)水平升高与低核级别相关(P=0.01)。在5年的随访中，JAB1和p27(Kip1)的表达均与无病生存期无关。结论JAB1在浸润性乳腺癌中普遍过表达。在无淋巴结转移的乳腺癌中，JAB1的过度表达与低水平的p27(Kip1)相关。在本研究中，JAB1和p27(Kip1)不是独立的预后因素。
PURPOSE The purpose is to evaluate expression levels of Jun activation domain-binding protein 1 (JAB1) in breast cancer tissue and adjacent normal tissue, to determine whether JAB1 expression is associated with p27(Kip1) expression in invasive breast carcinomas, and to evaluate the prognostic significance of JAB1 and p27(Kip1) in node-negative breast cancer. EXPERIMENTAL DESIGN JAB1 levels were measured in 10 matched pairs of invasive breast tumor tissue and adjacent normal tissue using Western blot analysis. We also investigated the immunoreactivity of JAB1 and p27(Kip1) levels in paraffin-embedded tissue specimens from 220 patients with node-negative breast cancer who had not received adjuvant systemic therapy. The median follow-up was 15 years. RESULTS JAB1 was expressed at higher levels in invasive tumors than in adjacent normal tissue (P = 0.01). JAB1 overexpression was observed in 57% of invasive breast cancers. Low levels of p27(Kip1) were noted in 70% of the tumor specimens. We found an inverse correlation between JAB1 and p27(Kip1) expression levels (P = 0.01). JAB1 overexpression was associated with patient age of at least 50 years (P = 0.03) and tumor size of </=2 cm (P = 0.01). Elevated levels of p27(Kip1) were associated with low nuclear grade (P = 0.01). At 5 years of follow-up, neither JAB1 nor p27(Kip1) expression was related to disease-free survival. CONCLUSIONS These data indicate that JAB1 is commonly overexpressed in invasive breast carcinomas. JAB1 overexpression is associated with low levels of p27(Kip1) in node-negative breast cancer. In this study, JAB1 and p27(Kip1) were not independent prognostic factors.