Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
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DOI：
10.1016/j.arabjc.2014.05.006
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发表时间：
2017-05-01
影响因子：
6
通讯作者：
Abubshait, Samar A.
中科院分区：
文献类型：
--
作者：
El-Hady, Heba A.;Abubshait, Samar A.
由恶唑烷酮衍生物(2a-c)与苯胺和2-羟基苯胺缩合，合成了一系列咪唑烷酮和苯并恶唑衍生物(3和5)。以化合物3和5为原料，与乙酸酐和氯乙酰氯进行乙酰化反应，制得乙酰基衍生物(4、6和7)。结果表明，咪唑烷酮和苯并恶唑类化合物对癌细胞株MCF-7和HepG2有较强的抑制作用。特别是，苯并恶唑类化合物比咪唑酮类化合物更有效。(C)2014年沙特国王大学。爱思唯尔B.V.制作和主办。
A series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by the condensation of oxazolinone derivatives (2a-c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4, 6 and 7) were prepared via acetylation of compounds 3 and 5 with acetic anhydride and chloroacetyl chloride. The results revealed that imidazolinone and benzoxazole derivatives are potent against the cancer cell lines MCF-7 and HePG2. In particular, benzoxazole derivatives are more potent than imidazolinone derivatives. (c) 2014 King Saud University. Production and hosting by Elsevier B.V.