Maternal Plasma and Cord Blood Concentration Profiles of Duloxetine During the Peripartum Period and Their Associations With the Modified Finnegan Score
Maternal Plasma and Cord Blood Concentration Profiles of Duloxetine During the Peripartum Period and Their Associations With the Modified Finnegan Score
复制标题
围产期母体血浆和脐带血浓度分布及其与改良芬尼根评分的关系
DOI：
10.1097/ftd.0000000000000943
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发表时间：
2022
影响因子：
2.5
通讯作者：
Kawakami Junichi
中科院分区：
文献类型：
--
作者：
Taguchi Reina;Naito Takafumi;Suzuki Koji;Kurosawa Yuko;Itoh Hiroaki;Kawakami Junichi
我们检查了2名接受口服度洛沙汀治疗抑郁症状的孕妇。在围产期期间，获得了一名女性的度洛沙汀母体血浆浓度曲线以及沿着脐带血浓度曲线。新生儿戒断综合征（NAS）分娩后的症状也进行了监测，据报道，7%-12%的孕妇在围产期出现抑郁症状。1进入母体循环的抗抑郁药可能在某种程度上通过胎盘，由于通过脐带暴露，可能对胎儿造成风险。大约30%接触抗抑郁药的新生儿会出现NAS。2.妊娠期抑郁症的复发率在中断抗抑郁药物治疗后增加了约5倍。3需要了解围产期度洛塞汀血药浓度特征及其与新生儿NAS发作的关系，以评估妊娠期间度洛塞汀治疗的风险。
We examined 2 pregnant women receiving oral duloxetine for depressive symptoms. During the peripartum period, maternal plasma concentration profiles of duloxetine were obtained for both along with cord blood concentration profile in one woman. The symptoms of neonatal abstinence syndrome (NAS) after delivery were also monitored.According to reports, 7%–12% of pregnant women experience depressive symptoms during the peripartum period. 1 Antidepressants that enter the maternal circulation potentially pass through the placenta to some extent and can be a risk to the fetus because of exposure through the umbilical cord. Approximately 30% of neonates exposed to antidepressants experience NAS. 2 The recrudescence rate of depression during the gestation period shows an approximate of 5-fold increase in turn interrupting the antidepressants. 3 Information on the plasma concentration profile of duloxetine during the peripartum period and its relationship with NAS onset in neonates is required for assessing the risk of duloxetine therapy during pregnancy.