Brain aging in normal Egyptians: cognition, education, personality, genetic and immunological study
Brain aging in normal Egyptians: cognition, education, personality, genetic and immunological study
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DOI：
10.1016/s0022-510x(03)00032-7
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发表时间：
2003-07-15
影响因子：
4.4
通讯作者：
El Faiuomy, N
中科院分区：
文献类型：
--
作者：
Elwan, O;Madkour, O;El Faiuomy, N
研究老年期发生的认知和免疫变化以及遗传功能已被认为是区分正常脑老化与早期痴呆特别是阿尔茨海默病的重要课题。本研究的目的是强调年龄相关的神经心理和电生理（P-300）在正常埃及受试者的变化，阐明遗传（载脂蛋白e- 4基因型）和免疫标记物{白细胞介素6 （IL-6）和细胞间粘附分子（ICAM-1）在血清中的价值}作为早期检测大脑衰老认知能力下降的工具。94名正常的埃及受试者（60岁以下和60岁以上）接受了以下研究：(1)记忆、知觉、精神运动表现和注意力的神经心理学测试，(2)艾森克人格问卷（EPQ）人格特征测试，(3)事件相关电位研究（P-300、潜伏期和振幅），(4)载脂蛋白E基因型检测的基因测试，(5)血清中IL-6和ICAM-1水平检测的免疫学研究。老年受试者，尤其是男性和受教育程度低的受试者在记忆、精神运动表现和知觉方面存在显著的障碍。在人格方面，老年人EPQ神经质量表得分显著较高。载脂蛋白E-3/E-3是埃及人最常见的基因型（49.1%）。结果发现，携带Apo-E-4基因型的被试在有意记忆（感觉记忆）测试中的得分较其他基因型差。高IL-6水平的受试者在注意和感觉记忆方面存在显著的损伤。这在高ICAM-1水平的受试者中未被检测到。综上所述，年龄的增长和教育水平的降低被认为是正常大脑衰老中认知能力下降的危险因素。神经心理学测试仍然是检测早期认知障碍的高度敏感的工具。神经质的特征在老年时更常见。载脂蛋白e -4基因型与显著的感觉（故意）记忆障碍有关。血清中高水平的IL-6伴随着注意力和感觉（有意）记忆的显著损伤。(C) 2003 Elsevier Science b.v.版权所有
Studying the cognitive and immunological changes that occur in old age as well as genetic function have been considered an important Subject to differentiate between normal brain aging and early dementia especially Alzheimer's disease. The aim of this study is to stress on age-related neuropsychological and electrophysiological (P-300) changes in normal Egyptian subjects, to throw light on the value of genetic (Apo-E-4 genotype) and immunological markers {interleukin-6 (IL-6) and intercellular adhesion molecules (ICAM-1) in the serum} as tools used in early detection of cognitive decline in cerebral aging. Ninety-four normal Egyptian subjects (below and above 60 years) were submitted to the following: (1) neuropsychological tests for testing memory, perception, psychomotor performance and attention, (2) Eysenck Personality Questionnaire (EPQ) for personality traits, (3) event-related potential study (P-300, latency and amplitude), (4) genetic test for detection of Apolipoprotein E genotype and (5) immunological studies including detection of the level of IL-6 and ICAM-1 in serum. There was a significant impairment of memory, psychomotor performance and perception in elderly Subjects particularly males and subjects with low level of education. Regarding personality, significantly high scores were obtained in neuroticism scale of EPQ in elderly subjects. Apo-E-3/E-3 was genotype did significantly the most common genotype encountered in Egyptian subjects (49.1%). It was found that subjects with Apo-E-4 worse in scores of intentional memory test (sensory memory) when compared with other genotypes. Statistically significant impairment in attention and sensory memory was found in subjects with high IL-6 level. This could not be detected in subjects with high ICAM-1 level. In conclusion, advancing age and lower levels of education are considered risk factors for cognitive decline in normal brain aging. Neuropsychological tests remain as the highly sensitive tools for detection of early cognitive impairment. Neurotic traits are more encountered in old age. Apo-E-4 genotype is associated with significant sensory (intentional) memory impairment. High IL-6 level in the serum is accompanied by significant impairment in attention and sensory (intentional) memory. (C) 2003 Elsevier Science B.V All rights reserved.