Cryptosporidium parvum infection requires host cell actin polymerization
Cryptosporidium parvum infection requires host cell actin polymerization
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DOI：
10.1128/iai.69.9.5940-5942.2001
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发表时间：
2001-09-01
影响因子：
3.1
通讯作者：
Clark, DP
中科院分区：
文献类型：
--
作者：
Elliott, DA;Coleman, DJ;Clark, DP
细胞内原生动物寄生虫小隐孢子虫（Cryptosporidium parvum）在其与宿主细胞质的交界处积累宿主细胞肌动蛋白。在这里，我们发现肌动蛋白聚合蛋白Arp2/3、血管扩张剂刺激磷酸化蛋白（VASP）和神经Wiskott Aldrich综合征蛋白（N-WASP）存在于这个界面，宿主细胞肌动蛋白聚合是寄生虫感染所必需的。
The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.