An abnormality in steroid reductive metabolism in a hypertensive syndrome.
An abnormality in steroid reductive metabolism in a hypertensive syndrome.
复制标题
高血压综合征中类固醇还原代谢异常。
DOI：
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发表时间：
1977
影响因子：
5.8
通讯作者：
M. I. New
中科院分区：
文献类型：
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作者：
S. Ulick;Leyla C. Ramirez;M. I. New
对与血浆肾素活性抑制和低钾血症相关的青少年高血压综合征的研究未能揭示醛固酮或任何其他已知类固醇的过量产生。然而，未结合的尿类固醇分数异常增加。在给予标记的皮质醇后对该部分的分析显示，它主要由在4，5或C-20处减少的二氢代谢物组成，并且4，5-二氢部分含有相对于5 β-代谢物的5 α-异常增加。然而，在环A完全还原形成四氢衍生物方面没有绝对缺陷。这些发现，以及Marver和Edelman关于5 α-二氢皮质醇可能是一种有效的盐皮质激素的观察结果，提示代谢异常与患者的高血压疾病之间可能存在病因学关系。
Studies in a juvenile hypertensive syndrome associated with suppressed plasma renin activity and hypokalemic alkalosis failed to reveal overproduction of aldosterone or any other known steroid. There was however an abnormal increase in the fraction of unconjugated urinary steroids. Analysis of this fraction following the administration of labeled cortisol revealed that it was largely composed of dihydro metabolites reduced either at 4,5 or at C-20 and that the 4,5-dihydro fraction contained an abnormal increase in 5alpha- relative to 5beta-metabolites. There was, however, no absolute defect in the complete reduction of ring A to form tetrahydro derivatives. These findings, together with observations by Marver and Edelman that 5alpha-dihydrocortisol may be an effective mineralcorticoid, suggest the possibility of an etiologic relationship between the metabolic abnormality and the patient's hypertensive disorder.