Ipsapirone depresses neuronal activity in the dorsal raphe nucleus and the hippocampal formation.
Ipsapirone depresses neuronal activity in the dorsal raphe nucleus and the hippocampal formation.
复制标题
伊沙匹隆抑制中缝背核和海马结构的神经元活动。
DOI：
10.1016/0014-2999(86)90194-9
复制
发表时间：
1986
影响因子：
5
通讯作者：
G. Rebec
中科院分区：
文献类型：
--
作者：
A. Basse;G. Rebec
伊普沙普龙是一种对5-HT1结合位点具有高亲和力的新型抗焦虑药物，它能抑制乌拉坦麻醉大鼠中缝背核和海马区的神经元活动。在海马区，齿状颗粒细胞与中缝背侧5-羟色胺神经元的反应性相匹配，抑制50%的半数有效剂量为125.0μg/kg。相反，CA1区锥体细胞的反应与基线放电频率直接相关。例如，慢放电神经元被31.3μg/kg抑制，而快放电神经元即使在500.0μg/kg剂量下也没有反应。这些结果表明，在5-HT1A受体密度较高的部位，爱普沙酮对神经元活动有很强的影响。
Ipsapirone, a putative, novel anxiolytic with a high affinity for 5-HT1Abinding sites, suppressed neuronal activity in both the dorsal raphe nucleus and hippocampal formation of urethane-anesthetized rats. In the hippocampus, dentate granule cells matched the responsiveness of dorsal raphe serotonin neurons, the median effective dose for 50% inhibition being 125.0 μg/kg in both areas. In contrast, the responses of CA1 pyramidal cells were related directly to baseline firing rates. Slow-firing neurons, for example, were inhibited by 31.3 μg/kg and fast-firing cells were unresponsive even up to a dose of 500.0 μg/kg. These results indicate a potent effect of ipsapirone on neuronal activity in sites with a high density of 5-HT1Areceptors.