Human Bisphenol A Exposure and the "Diabesity Phenotype".
Human Bisphenol A Exposure and the "Diabesity Phenotype".
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DOI：
10.1177/1559325815599173
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Battezzati A
中科院分区：
文献类型：
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作者：
Bertoli S;Leone A;Battezzati A
双酚A （BPA）是一种已知的内分泌干扰物，是一种食品污染物，被怀疑是当今肥胖、糖尿病和心血管疾病增加的一个因素。这一问题在糖尿病研究领域引起了越来越多的关注，并已成为监管机构和食品行业关注的问题。近年来，涉及双酚a的研究数量呈指数级增长，但在双酚a实际暴露与心脏代谢风险之间的关系以及食物摄入暴露方式的知识方面仍有许多空白，所有这些都妨碍了对人类健康风险的合理判断。本文综述了BPA暴露与肥胖、甲状腺功能、糖尿病、胰岛素抵抗、代谢综合征、心血管疾病和食品中BPA含量的关系。许多横断面研究支持（有时是相互矛盾的）BPA暴露对肥胖、糖尿病和心血管疾病的不利影响。很少有前瞻性研究支持BPA暴露对这些病理的不利影响。此外，没有进行干预研究来评估这种关联的因果关系。这主要是由于缺乏食品中双酚a含量的适当数据库，从而阻碍了对通常饮食中双酚a摄入量的任何估计。
Bisphenol A (BPA), a known endocrine disruptor, is a food contaminant suspected of being a contributing factor to the present-day increase in obesity, diabetes, and cardiovascular disease. This issue is of increasing interest in the field of diabetes research and has become a matter of concern for regulatory agencies and food industries. Recently, the number of studies involving BPA has increased exponentially, but there are still many gaps in the knowledge of the relationship between actual BPA exposure and cardiometabolic risk and of the modalities of food intake exposure, all of which prevents sound judgments concerning the risks to human health. This review focuses on the association between human exposure to BPA and obesity, thyroid function, diabetes, insulin resistance, metabolic syndrome, cardiovascular diseases, and BPA content in food. Many cross-sectional studies support, sometimes contradictorily, an adverse effect of BPA exposure on obesity, diabetes, and cardiovascular diseases. Few prospective studies support an adverse effect of BPA exposure on such pathologies. Moreover, no intervention studies have been conducted to evaluate the causality of such associations. This is mainly due to lack of an appropriate database of BPA content in foods, thus hindering any estimation of the usual dietary BPA intake.