EXPOSURES AND MORTALITY AMONG CHRYSOTILE ASBESTOS WORKERS .2. MORTALITY
EXPOSURES AND MORTALITY AMONG CHRYSOTILE ASBESTOS WORKERS .2. MORTALITY
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DOI：
10.1002/ajim.4700040304
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发表时间：
1983-01-01
影响因子：
3.5
通讯作者：
SHY, CM
中科院分区：
文献类型：
--
作者：
DEMENT, JM;HARRIS, RL;SHY, CM
一项回顾性队列死亡率研究在 1940 年至 1975 年间对 1,261 名在温石棉纺织行业工作了 1 个月或以上的白人男性进行了跟踪调查。观察到所有原因综合死亡率（标准化死亡率 [SMR] = 150）、肺癌（SMR = 135）、循环系统疾病（SMR = 125）、非恶性呼吸道疾病的死亡率显着超额。疾病（SMR = 294）和事故（SMR = 134）。使用估计的纤维暴露水平与详细的工人工作历史相结合，研究了暴露-反应关系。观察到肺癌和石棉相关非恶性呼吸系统疾病存在很强的暴露-反应关系。与温石棉矿工和磨坊主的数据相比，温石棉纺织工人在较低的终生累积暴露水平下的肺癌死亡率明显更高。空气中纤维特性的差异等因素可能部分解释了纺织工人与矿工和磨坊主之间暴露反应的巨大差异。
A retrospective cohort mortality study was conducted among a cohort of 1261 white males employed 1 or more months in chrysotile asbestos textile operations and followed between 1940 and 1975. Statistically significant excess mortality was observed for all causes combined (standardized mortality ratio [SMR] = 150), lung cancer (SMR = 135), diseases of the circulatory system (SMR = 125), nonmalignant respiratory diseases (SMR = 294) and accidents (SMR = 134). Using estimated fiber exposure levels in conjunction with detailed worker job histories, exposure-response relationships were investigated. Strong exposure-response relationships for lung cancer and asbestos related nonmalignant respiratory diseases were observed. Compared with data for chrysotile miners and millers, chrysotile textile workers experienced significantly greater lung cancer mortality at lower lifetime cumulative exposure levels. Factors such as differences in airborne fiber characteristics may partially account for the large differences in exposure response between textile workers and miners and millers.