Cytoplasmic inheritance of a cell surface antigen in the mouse.
Cytoplasmic inheritance of a cell surface antigen in the mouse.
复制标题
小鼠细胞表面抗原的细胞质遗传。
作者：
K. F. Lindahl;Barbara Hausmann
Mta是小鼠的细胞表面抗原，并作为特异性T杀伤淋巴细胞的靶标。使用杀伤细胞试验，在72种实验室小鼠中发现了该抗原，除一种例外，在所有野生或繁殖的小鼠样品中发现了该抗原，包括Mus molossinus，Mus castaneus和Mus spretus。5个品系的大鼠、非近交系NMRI小鼠、NZB小鼠的大多数亚系和密切相关的品系NZO均为Mta阴性。在几个Mta+和两个Mta-菌株之间的相互F1杂交中，抗原是母系传播的;也就是说，Mta+雌性只产生阳性后代，而Mta-雌性只产生阴性后代，无论雄性的基因型如何。由于34只寄养的小鼠具有遗传母亲的Mta类型，因此决定Mta表达的因子必须在出生前传播，而不是通过乳汁传播。通过反复回交，Mta+菌株的细胞质基因与Mta-菌株的染色体基因结合，反之亦然。所有后代都保留了其母系的Mta类型。因此，Mta型完全由母系遗传决定，不受染色体基因的影响。我们没有发现Mta-和Mta+菌株的细胞质因子和核基因之间不相容的证据。
Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneus and Mus spretus. Five strains of rats, non-inbred NMRI mice, most substrains of NZB mice and the closely related strain NZO are negative for Mta. In reciprocal F1 crosses between several Mta+ and two Mta- strains, the antigen is maternally transmitted; that is, Mta+ females bear only positive offspring, whereas Mta- females bear only negative offspring, regardless of the genotype of the male. Since 34 foster-nursed mice had the Mta type of their genetic mothers, the factor that determines expression of Mta must be transmitted before birth and not via the milk. The cytoplasmic genes of Mta+ strains have been combined with the chromosomal genes of Mta- strains, and vice versa, by repeated backcrossing. All progeny retained the Mta type of their maternal lines. Thus, the Mta type is determined solely by maternal inheritance and is not influenced by chromosomal genes. We found no evidence of incompatibility between the cytoplasmic factors and nuclear genes of Mta- and Mta+ strains.