The moderating effects of tension-reduction alcohol outcome expectancies on placebo responding in individuals with social phobia
The moderating effects of tension-reduction alcohol outcome expectancies on placebo responding in individuals with social phobia
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DOI：
10.1016/j.addbeh.2004.03.020
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发表时间：
2004-08-01
影响因子：
4.4
通讯作者：
Kushner, MG
中科院分区：
文献类型：
--
作者：
Abrams, K;Kushner, MG
我们证实，在酒精安慰剂研究中，紧张减轻酒精结果预期（TR-AOE）的个体差异可能会对操纵产生广泛不同的反应，并通过让社交恐惧症患者在一组人面前演讲来验证这一观点。一次演讲发生在参与者饮用安慰剂饮料或对照饮料之前，一次演讲发生在参与者饮用安慰剂饮料或对照饮料之后（即，不含酒精的饮料）。研究结果表明，安慰剂操作减少焦虑的认知和情感症状，在更大程度上为男性与高TR-AOE比男性与低TR-AOE。在安慰剂组的女性或对照组的个体中没有发现这种模式。这些发现表明TR-AOE对安慰剂饮料的消费和对焦虑挑战的反应之间的关联具有调节作用，并强调了在评估精神活性物质时考虑性别和结果预期的重要性。(C)2004爱思唯尔有限公司保留所有权利。
We conjectured that individual differences in tension-reduction alcohol outcome expectancies (TR-AOEs) could produce widely varying responses to manipulations in alcohol-placebo studies and tested this idea by having individuals with social phobia give speeches in front of a group. One speech occurred before and one after participants consumed either a placebo beverage or a control beverage (i.e., a nonalcoholic drink described as containing no alcohol). Study results indicate that the placebo manipulation reduced cognitive and affective symptoms of anxiety to a greater extent for males with high TR-AOEs than for males with low TR-AOEs. This pattern was not found for women in the placebo group or for individuals in the control group. These findings demonstrate a moderating effect of TR-AOEs on the association between the consumption of a placebo beverage and response to an anxiety challenge and highlight the importance of accounting for gender and outcome expectancies when evaluating psychoactive substances. (C) 2004 Elsevier Ltd. All rights reserved.