Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells
Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells
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DOI：
10.1016/s1286-4579(00)00294-x
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发表时间：
2000-03-01
影响因子：
5.8
通讯作者：
Colonna, M
中科院分区：
文献类型：
--
作者：
Dietrich, J;Nakajima, H;Colonna, M
越来越多的证据表明，骨髓细胞表达几个受体家族，其中包括抑制性和刺激性同种异构体。具有相似特异性但功能相反的受体异构体在同一细胞上的表达是有趣的。这些受体之间的相互作用是什么呢？最近对两个骨髓受体家族的研究可能会给这个问题的答案提供一些线索：ILT/LIR/MIR（免疫球蛋白样转录物/白细胞igg样受体/单核细胞/巨噬细胞igg样受体）和SIRP（信号调节蛋白）。(C) 2000年版《科学与医学》Elsevier SAS。
There is increasing evidence that myeloid cells express several receptor families, which include both inhibitory and stimulatory isoforms. The expression of receptor isoforms with similar specificities but opposite functions on the same cell is intriguing. What might be the interplay between these receptors! Some clues to the answer to this question may come from recent studies on two myeloid receptor families: the ILT/LIR/MIR (immunoglobulin-like transcript/leukocyte Ig-like receptor/monocyte/macrophage Ig-like receptor) and the SIRP (signal-regulatory protein). (C) 2000 Editions scientifiques et medicales Elsevier SAS.