Amphibian (urodele) myotomes display transitory anterior/posterior and medial/lateral differentiation patterns.
Amphibian (urodele) myotomes display transitory anterior/posterior and medial/lateral differentiation patterns.
复制标题
两栖动物（urodele）肌节表现出短暂的前/后和内侧/外侧分化模式。
DOI：
10.1016/0012-1606(89)90248-0
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发表时间：
1989
影响因子：
2.7
通讯作者：
Chung,HM
中科院分区：
文献类型：
--
作者：
Neff,AW;Malacinski,GM;Chung,HM
采用抗肌动蛋白和抗肌球蛋白单克隆抗体作为分子探针，对墨西哥钝口螈（Ambystoma mexicanum）体节发生过程中的肌节分化进行了分析。肌节分化发生在分割后，并沿着体节文件的头尾方向进行。在个体体节内，肌节分化显示出不同的极性。在尾芽阶段体节文件的检查显示，分割后不久，肌动蛋白/肌球蛋白主要积累在肌节的前部和内侧区域最初。随后，肌节内的细胞在前后和内外方向上分化。分割前的preomitic近轴中胚层移植物的实验分析表明，这种短暂的肌节极性是自主的。比较分析表明，这种肌节分化模式是有尾目特有的。Cynops pyrrhogaster经历肌节分化一样的蝾螈，而两个无尾类，非洲爪蟾和铃蟾东方，没有。
Myotome differentiation during Mexican axolotl (Ambystoma mexicanum) somitogenesis was analyzed by employing anti-actin and anti-myosin monoclonal antibodies as molecular probes. Myotome differentiation occurs after segmentation and proceeds in the cranial-to-caudal direction along the somite file. Within individual somites myotome differentiation displays distinct polarities. Examination of the somite file at the tailbud stage revealed that soon after segmentation, actin/myosin accumulate predominantly in the anterior and medial region of the myotome initially. Subsequently, cells within the myotome differentiate in an anterior-to-posterior and medial-to-lateral direction. Experimental analysis of presomitic paraxial mesoderm grafts before segmentation revealed that this transient myotome polarity is autonomous. Comparative analyses indicate that this myotome differentiation pattern is urodele specific.Cynops pyrrhogasterundergoes myotome differentiation like the axolotl, while two anurans,Xenopus laevisandBombina orientalis, do not.