Introducing a Virtual Lesion Model of Dysphagia Resulting from Pharyngeal Sensory Impairment.
Introducing a Virtual Lesion Model of Dysphagia Resulting from Pharyngeal Sensory Impairment.
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DOI：
10.1159/000487037
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Suntrup-Krueger, Sonja
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文献类型：
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作者：
Muhle, Paul;Claus, Inga;Suntrup-Krueger, Sonja
背景/目的：在严重受累的患者中进行神经生理学和功能成像研究以研究用于治疗神经源性吞咽困难的新型神经刺激技术是困难的。因此，基础研究需要在健康受试者中进行。吞咽是一种高度依赖于感觉传入输入的运动功能。在这里，我们提出了一个虚拟的外周感觉病变模型，以模仿咽部感觉障碍，这是已知的一个主要贡献者吞咽困难的神经diseases.METHODS：在这个随机交叉研究对11名健康志愿者，皮质激活在气动咽刺激测量应用脑磁图在两个单独的会议，有和没有咽表面麻醉。刺激诱发的双侧事件相关去兴奋化（ERD）主要在尾外侧中央周围皮层。与无麻醉条件相比，表面麻醉导致β（13-30 Hz）和低γ（30-60 Hz）频率范围内的ERD降低（p
BACKGROUND/AIMS: Performing neurophysiological and functional imaging studies in severely affected patients to investigate novel neurostimulation techniques for the treatment of neurogenic dysphagia is difficult. Therefore, basic research needs to be conducted in healthy subjects. Swallowing is a motor function highly dependent on sensory afferent input. Here we propose a virtual peripheral sensory lesion model to mimic pharyngeal sensory impairment, which is known as a major contributor to dysphagia in neurological disease.METHODS: In this randomized crossover study on 11 healthy volunteers, cortical activation during pneumatic pharyngeal stimulation was measured applying magnetoencephalography in two separate sessions, with and without pharyngeal surface anesthesia.RESULTS: Stimulation evoked bilateral event-related desynchronization (ERD) mainly in the caudolateral pericentral cortex. In comparison to the no-anesthesia condition, topical anesthesia led to a reduction of ERD in beta (13-30 Hz) and low gamma (30-60 Hz) frequency ranges (p