Molecular organization of tricellular tight junctions.
Molecular organization of tricellular tight junctions.
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DOI：
10.4161/tisb.28960
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发表时间：
2014
期刊：
影响因子：
3.1
通讯作者：
Iwamoto N
中科院分区：
文献类型：
--
作者：
Furuse M;Izumi Y;Oda Y;Higashi T;Iwamoto N
当上皮细胞的顶侧边界与多边形相比时，其侧边对应于顶端连接复合体，其中细胞粘附分子从两个相邻细胞的质膜组装。另一方面，它的顶点对应于三细胞接触，三个细胞的角相遇。脊椎动物的三细胞接触具有特殊的紧密连接结构，称为三细胞紧密连接（tTJ）。tTJ在40多年前通过电子显微镜观察鉴定，但从那时起在上皮细胞生物学中基本上被遗忘。鉴定的tricellulin和angulin家族蛋白的tTJ-相关的膜蛋白，使我们能够研究tTJ的不仅是细胞旁屏障功能，但也未知的特征，上皮细胞角落通过分子生物学方法。
When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the corners of three cells meet. Vertebrate tricellular contacts have specialized structures of tight junctions, termed tricellular tight junctions (tTJs). tTJs were identified by electron microscopic observations more than 40 years ago, but have been largely forgotten in epithelial cell biology since then. The identification of tricellulin and angulin family proteins as tTJ-associated membrane proteins has enabled us to study tTJs in terms of not only the paracellular barrier function but also unknown characteristics of epithelial cell corners via molecular biological approaches.