Cancer: HDL cholesterol and cancer risk.
Cancer: HDL cholesterol and cancer risk.
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DOI：
10.1038/nrgastro.2011.52
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Greenhill, Claire
中科院分区：
文献类型：
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作者：
Greenhill, Claire
代谢综合征的特征是脂质和脂蛋白水平的改变，高血压和高葡萄糖浓度，与结直肠癌（CRC）的风险增加有关。然而，“很少有研究探讨了与CRC风险相关的脂质和脂蛋白浓度的单独成分，”作者Bas Bueno-de-Mesquita解释说。作为欧洲癌症与营养前瞻性调查（EPIC）研究的一部分，研究人员调查了这种潜在的关联。EPIC包括超过520，000名参与者，他们完成了饮食和生活方式问卷，并在招募时提供了血液样本。在这些参与者中，有1，238人在研究期间患上了CRC。研究人员比较了患有CRC的参与者的基线血液样本中HDL胆固醇和载脂蛋白A的水平与1，238名对照个体的血液样本。
The metabolic syndrome, which is characterized by altered levels of lipids and lipoproteins, high blood pressure and high glucose concentrations, is linked with an increased risk of colorectal cancer (CRC). However,“few studies have explored the separate component of lipid and lipoprotein concentrations in relation to CRC risk,” explains author Bas Bueno-de-Mesquita. The researchers investigated this potential association as part of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.EPIC included> 520,000 participants who completed a dietary and lifestyle questionnaire and gave a blood sample when they were recruited to the study. Of these participants, 1,238 developed CRC during the study. The researchers compared the levels of HDL cholesterol and apolipoprotein A in the baseline blood samples of the participants who developed CRC with the blood samples of 1,238 control individuals.