ORIGIN OF BILATERIAN BODY PLANS - EVOLUTION OF DEVELOPMENTAL REGULATORY MECHANISMS
ORIGIN OF BILATERIAN BODY PLANS - EVOLUTION OF DEVELOPMENTAL REGULATORY MECHANISMS
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DOI：
10.1126/science.270.5240.1319
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发表时间：
1995-11-24
期刊：
影响因子：
56.9
通讯作者：
CAMERON, RA
中科院分区：
文献类型：
--
作者：
DAVIDSON, EH;PETERSON, KJ;CAMERON, RA
一个论点是提出来解释大型后生动物的起源，基于监管过程的基础上，在现代动物的形态发生组织模式。遗传调控系统类似于现代，间接发展的海洋无脊椎动物被认为是指示前寒武纪监管平台上竖立的创新，基础上的宏观身体计划的发展。这些系统是产生未指定的“预留细胞”组的遗传调节程序和根据转录因子表达的结构域最初定义形态发生空间区域的分级调节程序。这些想法影响了对节肢动物和脊索动物发育的解释以及对胚胎发生中同源异型复合体基因作用的解释。
An argument is proposed to explain the origin of large metazoans, based on the regulatory processes that underlie the morphogenetic organization of pattern in modern animals. Genetic regulatory systems similar to those used in modern, indirectly developing marine invertebrates are considered to indicate the Precambrian regulatory platform on which were erected innovations that underlie the development of macroscopic body plans. Those systems are genetic regulatory programs that produce groups of unspecified ''set-aside cells'' and hierarchical regulatory programs that initially define regions of morphogenetic space in terms of domains of transcription factor expression, These ideas affect interpretation of the development of arthropods and chordates as well as interpretation of the role of the genes of the homeotic complex in embryogenesis.