ZINC IN MULTIPLE-SCLEROSIS
ZINC IN MULTIPLE-SCLEROSIS
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DOI：
10.1002/ana.410140409
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
TESTA, MA
中科院分区：
文献类型：
--
作者：
DOREDUFFY, P;CATALANOTTO, F;TESTA, MA
对68例多发性硬化症患者、62例正常志愿者和13例其他神经系统疾病患者进行了锌谱检测。与对照组相比，多发性硬化症患者的血浆锌水平略有升高，而其他神经损害患者的血浆锌水平显著升高(P<；0.01)。在所有受试组中，白蛋白结合锌和蛋白质结合锌水平均正常。多发性硬化症患者α2-巨球蛋白结合锌水平显著低于对照组(P<；0.01)。多发性硬化患者红细胞结合锌水平显著高于对照组(P<；0.05)。在有其他神经损害的患者中，红细胞结合锌是正常的。由于红细胞结合的锌水平相对独立于每日膳食锌摄入量的波动，这些值的增加可能表明多发性硬化症患者锌区划的控制机制发生了变化。
Zn profiles were examined in 68 patients with multiple sclerosis, 62 normal volunteers and 13 patients with other neurological diseases. Plasma Zn levels were slightly increased in patients with multiple sclerosis and significantly increased in those with other neurological impairments (P < 0.01), compared with control subjects. Albumin-bound and protein-bound Zn levels were normal in all groups tested. The .alpha.2-macroglobulin-bound Zn level was significantly lower (P < 0.01) in patients with multiple sclerosis than in control subjects. Erythrocyte-bound Zn levels were significantly higher (P < 0.05) in patients with multiple sclerosis than in control subjects. Erythrocyte-bound Zn was normal in patients with other neurological impairments. Because erythrocyte-bound Zn levels are relatively independent of daily fluctuations in dietary Zn intake, an increase in these values may suggest alterations in the control mechanisms governing Zn compartmentalization in patients with multiple sclerosis.