Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
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DOI：
10.3109/00016340903322727
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Fasching, Peter A.
中科院分区：
文献类型：
--
作者：
Goecke, Tamme W.;Ekici, Arif B.;Fasching, Peter A.
客观的。评估妊娠相关症状与已知参与恶心和呕吐发病机制的基因中常见单核苷酸多态性 (SNP) 之间的关联。设计。在一项基于问卷调查的标准化访谈中，从对照组中选出进行关联研究的女性被回顾性地询问了她们第一次怀孕期间的恶心和呕吐情况。人口。共有 593 名至少完成过一次妊娠且可获得种系 DNA 的女性被选中。方法。使用聚合酶链式反应测试了血清素受体基因 HTR3A、HTR3B、HTR3C、HTR3D、HTR3E 和 NK1R (TACR1) 中的 8 个 SNP。恶心和呕吐的发生与患者的基因分型结果和病史参数相关。结果。第一次怀孕时的年龄和吸烟状况都与怀孕期间的呕吐和恶心显着相关。调整这两个参数后，两个 SNP rs6806362（每个等位基因的比值比 (OR) 1.38；95% 置信区间 (CI) 1.06-1.79；p = 0.017）和 rs6807670（OR 1.37；每个等位基因的 95% CI 1.05-1.79；p = 0.023）略有相关与怀孕相关的恶心。其他多态性均未显示出任何关联。结论。血清素受体亚基基因 HTR3C 的多态性可能与妊娠相关恶心的发病机制有关。
Objective. To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting. Design. In a standardized, questionnaire-based interview, women selected from a control cohort for association studies were asked retrospectively about nausea and vomiting during their first pregnancy. Population. A total of 593 women who had completed at least one pregnancy and for whom germline DNA was available were selected. Methods. Eight SNPs in the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D, HTR3E, and NK1R (TACR1) were tested using polymerase chain reaction. The occurrence of nausea and vomiting was correlated with the patients' genotyping results and medical history parameters. Results. Both young age at first pregnancy and positive smoking status were significantly associated with vomiting and nausea during pregnancy. After adjustment for these two parameters, the two SNPs rs6806362 (odds ratio (OR) 1.38 per allele; 95% confidence interval (CI) 1.06-1.79; p = 0.017) and rs6807670 (OR 1.37; 95% CI 1.05-1.79 per allele; p = 0.023) were marginally associated with pregnancy-related nausea. None of the other polymorphisms showed any association. Conclusion. Polymorphisms in the subunit gene HTR3C of the serotonin receptor may be involved in the pathogenesis of pregnancy-associated nausea.