Engagement of the PFC in consolidation and recall of recent spatial memory
Engagement of the PFC in consolidation and recall of recent spatial memory
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DOI：
10.1101/lm.1804410
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发表时间：
2010-06-01
影响因子：
2
通讯作者：
Cuello, A. Claudio
中科院分区：
文献类型：
--
作者：
Leon, Wanda C.;Bruno, Martin A.;Cuello, A. Claudio
系统巩固的标准模型提出，记忆最初依赖海马体，并随着时间的推移而成为海马体独立。先前的研究已经证明内侧前额叶皮层（mPFC）参与远程记忆的提取。使记忆经历系统巩固所需的转换被认为需要突触可塑性。在这项研究中，我们使用1-d训练协议研究了丝裂原活化蛋白激酶(MAPK)/ERK通路在莫里斯水迷宫（MWM）任务的习得、记忆巩固和近期记忆回忆中的参与。为此，将MEK抑制剂U0126双侧注射到大鼠mPFC中。在mPFC中注射MEK抑制剂不影响MWM的获得。然而，在学习阶段结束时（记忆巩固）或在保留测试之前使用MEK抑制剂会导致近期记忆检索的损害。这些结果有力地支持了最近获得和巩固的空间记忆需要mPFC的概念，并且mPFC中MAPK/ERK通路的局部激活对于巩固和回忆最近的记忆是必要的。
The standard model of system consolidation proposes that memories are initially hippocampus dependent and become hippocampus independent over time. Previous studies have demonstrated the involvement of the medial prefrontal cortex (mPFC) in the retrieval of remote memories. The transformations required to make a memory undergo system's consolidation are thought to require synaptic plasticity. In this study, we investigated the participation of the mitogen-activated protein kinase (MAPK)/ERK pathway in acquisition, memory consolidation, and recent memory recall of the Morris water maze (MWM) task using a 1-d training protocol. To this end, bilateral injections of the MEK inhibitor U0126 into the rat mPFC were performed. The injection of the MEK inhibitor in the mPFC did not affect the acquisition of the MWM. However, MEK inhibitor resulted in impairments on recent memory retrieval either when applied at the end of the learning phase (memory consolidation) or prior to the retention test. The results strongly support the concept that recently acquired and consolidated spatial memories require the mPFC, and that local activation of the MAPK/ERK pathway in the mPFC is necessary for the consolidation and recall of recent memories.