Population-based prevalence, type- and age-specific distribution of HPV in women before introduction of an HPV-vaccination program in Denmark
Population-based prevalence, type- and age-specific distribution of HPV in women before introduction of an HPV-vaccination program in Denmark
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DOI：
10.1002/ijc.23712
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发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Iftner, Thomas
中科院分区：
文献类型：
--
作者：
Kjaer, Susanne K.;Breugelmans, Gabrielle;Iftner, Thomas
了解人乳头瘤病毒（HPV）在人群中的流行情况非常重要。我们在丹麦进行了一项大型人群研究，以确定总体和年龄特异性HPV患病率以及女性HPV类型分布。连续收集液基细胞学样本（SurePath（R））。使用Hybrid Capture 2（HC 2; Digene）（高风险和低风险探针）进行HPV检测，并使用利帕（Innogenetics）进行基因分型。我们分析了来自11，617名女性的样本; 94.0%的细胞学正常，4.3%为意义不明的非典型鳞状细胞或低度鳞状上皮内病变，1.6%为高度鳞状上皮内病变（HSIL）。HPV感染率为26.4%，在20-24岁女性中达到峰值（50.2%），然后下降，在老年女性中没有第二个峰值。在最年轻的女性（15-19岁）中，14%患有HPV 16/18，16%患有HPV 6/11。高危型HPV的患病率从细胞学正常的妇女的19.2%增加到宫颈上皮内瘤变3级（CIN 3）/宫颈癌妇女的100%。HPV 16是最常见的类型（占所有妇女的6.0%），也是HSIL（35.1%）和CIN 3（53.2%）妇女中最常见的类型。其他常见的HPV类型包括HPV 52，51，31，33和18。HPV 16/18单独存在于23%的CIN 3病变和67%的宫颈癌中，HPV 16/18与其他高危型HPV一起存在于41%的CIN 3病变中。这表明有效的HPV 16/18疫苗将在一般女性人群中具有实质性的预防潜力。(C)2008 Wiley-Liss，Inc.
Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population-based study in Denmark to determine the overall and age-specific HPV prevalence, and HPV type distribution in women. Liquid-based cytology samples (SurePath (R)) were collected consecutively. HPV testing was performed with Hybrid Capture 2 (HC2; Digene) (high-risk and low-risk probes), and LiPA (Innogenetics) was used for genotyping. We analyzed samples from 11,617 women; 94.0% had normal cytology, 4.3% atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion and 1.6% had high-grade squamous intraepithelial lesion (HSIL). The HPV prevalence was 26.4% with a peak in women 20-24 years (50.2%) and then decreased without a second peak in older women. Among the youngest women (15-19 years) 14% had HPV 16/18 and 16% had HPV 6/11. Prevalence of high-risk HPV types increased from 19.2% in women with normal cytology to 100% in women with cervical intraepithelial neoplasia grade 3 (CIN3)/cervical cancer. HPV 16 was the most prevalent type (6.0% of all women), and was also the most prevalent in women with HSIL (35.1%) and CIN3 (53.2%). Other common HPV types in women with CIN3 included HPV 52, 51, 31, 33 and 18. HPV 16/18 alone was present in 23% or CIN3 lesions and 67% of cervical cancers, and HPV 16/18 together with other high-risk HPV types was present in 41% of CIN3 lesions. This suggests that an efficacious HPV 16/18 vaccine will have a substantial preventive potential in the general female population. (C) 2008 Wiley-Liss, Inc.