Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands
Nasopharyngeal carriage of Streptococcus pneumoniae and other bacteria in the 7th year after implementation of the pneumococcal conjugate vaccine in the Netherlands
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DOI：
10.1016/j.vaccine.2015.11.060
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发表时间：
2016-01-20
期刊：
影响因子：
5.5
通讯作者：
Sanders, Elisabeth A. M.
中科院分区：
文献类型：
--
作者：
Bosch, Astrid A. T. M.;van Houten, Marlies A.;Sanders, Elisabeth A. M.
2006年荷兰在婴幼儿国家免疫规划(NIP)中引入7价肺炎球菌结合疫苗(PCV7)后，出现了非疫苗血清型19A肺炎链球菌，并成为儿童及其父母携带的主要血清型。在其他欧洲国家和美国也观察到了类似的模式。金黄色葡萄球菌和非分型(NT)流感嗜血杆菌的携带率也有所增加。在2011年将PCV7改为I0价疫苗(PCV10)后，在2012/2013年冬季进行了一项新的携带者监测研究。采用常规培养方法，对330名接种PCV10疫苗的11月龄儿童和330名接种PCV7疫苗的24月龄儿童及其父母进行了鼻咽携带肺炎链球菌、流感嗜血杆菌、金黄色葡萄球菌和卡他莫拉氏菌的检测。将载运流行率与2005年、2009年和2010/2011年进行的类似载运研究进行了比较。虽然19A血清型仍然是儿童中最常见的肺炎球菌血清型，但接种PCV7的24个月儿童的19A患病率显著下降(14%至8%，p=0.01)，但在接种PCV10的11个月大的儿童中19A的患病率较低(12%至9%，p=0.31)。流感嗜血杆菌携带率保持稳定在较高水平(11个月婴儿的感染率为65%，24个月婴儿的感染率为69%)，而11个月大儿童的金黄色葡萄球菌携带率恢复到PCV7之前的水平(2010/2011年为14%，2012/2013年为7%)，但24个月婴儿的感染率(保持在7%)。我们的结果可能表明在鼻咽携带者中取代非疫苗肺炎球菌血清型和其他潜在致病菌之间的新平衡。携带性研究是评估疫苗对在人群中传播的病原体的影响、评估PCV影响以及预测呼吸道和侵袭性疾病变化的宝贵工具。(C)2015年提交人。爱思唯尔有限公司出版。
After introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the infant national immunization program (NIP) in the Netherlands in 2006, Streptococcus pneumoniae strains of the non-vaccine serotype 19A emerged and became the dominant serotype in carriage in children and their parents. Similar patterns were observed in other European countries and the United States. Increases in carriage rates of Staphylococcus aureus and non-typeable (NT) Haemophilus influenzae were also observed. After switching of PCV7 to I 0-valent vaccine (PCV10) in 2011, a new carriage surveillance study was performed in the winter of 2012/2013. Nasopharyngeal carriage of S. pneumoniae, H. influenzae, S. aureus, and Moraxella catarrhalis was determined by conventional culture in 330 PCV10-vaccinated 11-month-old children, 330 PCV7-vaccinated 24-month-old children, and their parents. Carriage prevalence was compared with similar carriage studies conducted in 2005, 2009, and 2010/2011. Although serotype 19A remained the most frequently carried pneumococcal serotype in children, prevalence of 19A significantly declined in PCV7-vaccinated 24-month-old children (14% to 8%, p = 0.01), but less in PCV10-vaccinated 11-month old children (12% to 9%, p = 0.31). Carriage of H. influenzae remained stable at an elevated level (65% in 11-month-olds and 69% in 24-month-olds), while the carriage of S. aureus returned to pre-PCV7 levels in 11-month-old children (14% in 2010/2011 to 7% in 2012/2013), but not in 24-month-olds (remained at 7%). Our results might indicate a new balance between replacing non-vaccine pneumococcal serotypes and other potential pathogenic bacteria in nasopharyngeal carriage. Carriage studies are valuable tools in assessing vaccine effects on pathogens circulating in the population, for evaluation of PCV impact, and in predicting changes in respiratory and invasive disease. (C) 2015 The Authors. Published by Elsevier Ltd.