Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets
Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets
复制标题
DOI：
10.1016/j.yrtph.2017.07.031
复制
发表时间：
2017-10-01
影响因子：
3.4
通讯作者：
Taranu, Ionelia
中科院分区：
文献类型：
--
作者：
Marin, Daniela E.;Pistol, Gina C.;Taranu, Ionelia
赭曲霉毒素A （OTA）是曲霉属和青霉属真菌产生的次生代谢物。OTA主要具有肾毒性，但也可引起肝毒性、诱变性、致畸性、神经毒性和免疫毒性。由于最近的研究强调了胃肠道和肾脏之间的密切关系，作为参与吸收和各自排泄的主要器官，本研究的目的是分析亚慢性暴露（30天）于0.05 mg/kg OTA对幼猪肠道和肾脏水平的免疫反应和氧化应激参数的影响。试验选用12头杂交断奶仔猪，随机分为对照组和毒素组，饲粮为0.050 mg OTA/kg。我们的研究结果表明，低剂量OTA亚慢性中毒30天会影响肠道和肾脏水平的免疫反应和抗氧化自卫。OTA中毒仔猪肠道炎症信号通路标志物和炎症细胞因子的基因表达受影响程度远高于肾脏。(C) 2017爱思唯尔公司版权所有。
Ochratoxin A (OTA) is a secondary metabolite produced by fungi of Aspergillus and Penicillium genra. OTA is mainly nephrotoxic but can also cause hepatotoxicity, mutagenicity, teratogenicity, neurotoxicity and immunotoxicity. As recent studies have highlighted the close relationship between gastrointestinal tract and kidney, as principal organs involved in absorption and respective excretion of xenobiotics, the aim of the present study was to analyze the effect of a subchronic exposure (30 days) to 0.05 mg/kg OTA on immune response and oxidative stress parameters at the level of intestine and kidney of young swine. The experiment was realised on twelve crossbred weaned piglets randomly allotted to both control group or toxin group fed 0.050 mg OTA/kg feed. Our results have shown that a subchronic intoxication with a low dose of OTA for 30 days affected the immune response and the anti-oxidant self-defense at gut and kidney level. The gene expression of both markers of signaling pathways involved in inflammation and inflammatory cytokines were affected in a much higher extent in the gut than in the kidney Of OTA intoxicated piglets. (C) 2017 Elsevier Inc. All rights reserved.