Measures of cortical plasticity after transcranial paired associative stimulation predict changes in electroencephalogram slow-wave activity during subsequent sleep.
Measures of cortical plasticity after transcranial paired associative stimulation predict changes in electroencephalogram slow-wave activity during subsequent sleep.
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DOI：
10.1523/jneurosci.1636-08.2008
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发表时间：
2008-07-30
期刊：
影响因子：
--
通讯作者：
Tononi G
中科院分区：
文献类型：
--
作者：
Huber R;Määttä S;Esser SK;Sarasso S;Ferrarelli F;Watson A;Ferreri F;Peterson MJ;Tononi G
Sleep slow wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the prior time awake and decreasing during sleep, though the underlying mechanisms are unclear. Recent studies have shown that procedures presumably leading to local plastic changes in the cerebral cortex can lead to local changes in SWA during subsequent sleep. To further investigate the connection between cortical plasticity and sleep SWA, in this study we employed a paired associative stimulation (PAS) protocol, in which median nerve stimuli were followed at different intervals (25 or 10 ms) by transcranial magnetic stimulation (TMS) pulses to the contralateral cortical hand area. As expected, such a protocol lead to a sustained increase (LTP-like) or decrease (LTD-like) of cortical excitability as measured by motor evoked potentials. By employing a TMS-compatible high-density electroencephalographic (EEG) system, we also found that, in individual subjects, TMS-evoked cortical responses over sensorimotor cortex changed with different interstimulus intervals. Moreover, during subsequent sleep, SWA increased locally in subjects whose TMS-evoked cortical responses had increased after PAS, and decreased in subjects whose cortical responses had decreased. Changes in TMS-evoked cortical EEG response and change in sleep SWA were localized to similar cortical regions and were positively correlated. Together, these results suggest that changes in cortical excitability in opposite directions lead to corresponding changes in local sleep regulation, as reflected by SWA, providing evidence for a tight relationship between cortical plasticity and sleep intensity.
