Approximating selective sweeps
Approximating selective sweeps
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DOI：
10.1016/j.tpb.2004.04.002
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发表时间：
2004-09-01
影响因子：
1.4
通讯作者：
Schweinsberg, J
中科院分区：
文献类型：
--
作者：
Durrett, R;Schweinsberg, J
在一个群体中固定有利突变具有减少该突变附近DNA序列变异的效果。Kaplan等人。(1989)使用一个三阶段模拟模型来研究选择性扫荡对家谱的影响。然而，大多数随后的工作简化了他们的方法，假设具有有利等位基因的个体数量遵循Logistic微分方程。我们证明了选择性扫描的影响可以精确地用折杆过程产生的随机划分来近似。我们的模拟结果表明，当具有优势等位基因的个体数量较少时，忽略随机性会导致很大的误差。(C)2004 Elsevier Inc.保留所有权利。
The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with the advantageous allele follows the logistic differential equation. We show that the impact of a selective sweep can be accurately approximated by a random partition created by a stick-breaking process. Our simulation results show that ignoring the randomness when the number of individuals with the advantageous allele is small can lead to substantial errors. (C) 2004 Elsevier Inc. All rights reserved.