Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors
Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors
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DOI：
10.1161/01.str.31.10.2426
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发表时间：
2000-10-01
期刊：
影响因子：
8.3
通讯作者：
Tremoli, E
中科院分区：
文献类型：
--
作者：
Baldassarre, D;Amato, M;Tremoli, E
背景和目的-B型超声测定的颅外颈动脉内膜中层厚度（IMT）是动脉粥样硬化存在的可测量指标。然而，迄今为止用于测量 IMT 的超声扫描协议和扫描读取技术非常耗时，并且需要专门研究中心的参与。在这项研究中，我们对意大利米兰 Enrica Grossi Paoletti 中心的 963 名患者进行了一项横断面研究，目的是评估在常规临床实践中颈动脉的超声测量是否能够产生与迄今为止临床试验中使用的定量方法获得的结果相同的结果。方法-使用机器的电子卡尺通过 B 型超声实时评估颈动脉的最大和平均最大 TMT。 结果-使用电子卡尺实时测量颈动脉IMT的观察者内和观察者间变异性与冷冻图像的定量处理相似（观察者内和观察者间平均最大IMT测量值的变异系数分别为4.2%和7.3%）。因此，测量的颈动脉 IMT 与大多数已知的动脉粥样硬化危险因素相关，并区分有和没有心血管事件史的患者。在整个组中以及将患者分为 3 个年龄组后，IMT 与血管危险因素总数呈线性相关。结论 - 这些观察结果建立了正常临床实践中评估的颈动脉粥样硬化 B 型成像与临床试验提供的数据之间的强相关性，并验证了这种简单的读取技术作为将 IMT 识别为血管疾病高风险患者的另一个可能危险因素的方法。
Background and Purpose-The intima-media thickness (IMT) of extracranial carotid arteries determined by B-mode ultrasound is a measurable index of the presence of atherosclerosis. The ultrasonographic scan protocol and the scan reading techniques used until now to measure IMT are, however, time consuming and require the participation of specialized research centers. in this study we present a cross-sectional study of 963 patients attending the Enrica Grossi Paoletti Center in Milan, Italy, with the aim of assessing whether ultrasonographic measurements of carotid artery in routine clinical practice can yield the same results as those obtained with quantitative methods used until now in clinical trials.Methods-Maximum and mean maximum TMT of carotid arteries were assessed by B-mode ultrasound with the use of the electronic caliper of the machine in real time.Results-The intraobserver and interobserver variability of IMT of carotid arteries performed with the electronic caliper in real time was similar to that of quantitative processing of frozen images (coefficients of variation of intraobserver and interobserver mean maximum IMT measurements were 4.2% and 7.3%, respectively). Carotid artery IMT thus measured correlated with most of the known atherosclerosis risk factors and discriminated between patients with and without previous history of cardiovascular events. IMT was linearly related to the total number of vascular risk factors both in the whole group and after stratification of patients into 3 age classes.Conclusions-These observations establish a strong correlation between B-mode imaging of carotid atherosclerosis evaluated in normal clinical practice and data provided by clinical trials and validate this simple reading technique as a means of identifying IMT as another possible risk factor in patients at high risk of vascular disease.