Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
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DOI：
10.1038/nn1649
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发表时间：
2006-03-01
影响因子：
25
通讯作者：
Poo, MM
中科院分区：
文献类型：
--
作者：
Lien, CC;Mu, YL;Poo, MM
局部GABA （c-氨基丁酸）回路有助于发育中的神经系统中依赖于感觉经验的神经元连接的改进，但GABA能突触本身是否能被感觉刺激迅速修改在很大程度上是未知的。在此，我们报道了在发育中的爪蟾视网膜顶系统中，视神经的重复光刺激或θ波爆发刺激（TBS）可诱导谷氨酸能输入的长期增强（LTP），而对同一顶神经元的gaba能输入的长期抑制（LTD）。这种限制是由于突触前GABA释放减少，需要突触前NMDA （n -甲基- d -天冬氨酸）受体（NMDARs）的激活和相应的高水平GABA能活性。因此，突触前NMDAR可能作为相邻谷氨酸能和gaba能活动的重合检测器，通过感觉经验导致协调的突触修饰。
Local GABA (c-aminobutyric acid) circuits contribute to sensory experience-dependent refinement of neuronal connections in the developing nervous system, but whether GABAergic synapses themselves can be rapidly modified by sensory stimuli is largely unknown. Here we report that repetitive light stimuli or theta burst stimulation (TBS) of the optic nerve in the developing Xenopus retinotectal system induces long-term potentiation (LTP) of glutamatergic inputs but long-term depression (LTD) of GABAergic inputs to the same tectal neuron. The LTD is due to a reduction in presynaptic GABA release and requires activation of presynaptic NMDA (N-methyl-D-aspartate) receptors (NMDARs) and coincident high-level GABAergic activity. Thus, the presynaptic NMDAR may function as a coincidence detector for adjacent glutamatergic and GABAergic activities, leading to coordinated synaptic modification by sensory experience.