Regulation of puberty
Regulation of puberty
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DOI：
10.1053/beem.2001.0176
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发表时间：
2002-03-01
影响因子：
7.4
通讯作者：
Delemarre-van de Waal, HA
中科院分区：
文献类型：
--
作者：
Delemarre-van de Waal, HA
青春期发育是促性腺激素释放激素(GnRH)活性变化的连续过程的最后一个阶段。青春期是否像最近在美国黑人人口中所描述的那样，倾向于在更小的年龄开始，仍然存在争议。这种早期发病在不同的欧洲国家还没有得到证实。在过去的几十年里，关于青春期开始时GnRH再次释放的潜在机制的想法已经发生了显着的变化。目前，普遍的观点是GnRH和其他调节神经元的神经元突起导致相互作用和活动的改变。性激素和各种中枢神经递质在调节GnRH释放方面发挥作用。出生后的积极释放伴随着童年的克制。GnRH兴奋活动的重新开始预示着青春期的开始。本章对涉及的许多因素进行了概述。
Pubertal development is the last phase of a continuum of changing gonadotrophin releasing hormone (GnRH) activities. Whether or not puberty tends to start at a younger age, as has been recently described in a population of black Americans, remains under debate. Such early onset has not been confirmed in different European countries. Ideas about the underlying mechanisms responsible for the reawakening of GnRH release at the onset of puberty have changed significantly during the last decades. At this moment, the common opinion is that neuronal outgrowth of both GnRH and other regulatory neurons results in changing interactions and activities.Sex steroids, as well as various central neurotransmitters, play a role in modulating GnRH release. Active release after birth is followed by the restraint of childhood. A re-onset of GnRH excitatory activities heralds the onset of puberty. This chapter gives an overview of the many factors involved.