Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: systemic arthritis and polyarthritis
Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: systemic arthritis and polyarthritis
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DOI：
10.1007/s10165-011-0540-6
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发表时间：
2012-08-01
影响因子：
2.2
通讯作者：
Yokota, Shumpei
中科院分区：
文献类型：
--
作者：
Ozawa, Remi;Inaba, Yutaka;Yokota, Shumpei
我们进行这项研究是为了调查系统性幼年特发性关节炎 (s-JIA) 和多关节炎 (p-JIA) 之间放射学和实验室检查结果的差异。 22 名 s-JIA 患者和 18 名 p-JIA 患者入组。他们的实验室检查结果和射线照片进行了回顾性检查。在生物制剂诱导之前获得平片。检查所有X光片是否存在软组织肿胀、关节旁骨质减少、关节间隙狭窄、软骨下骨囊肿、侵蚀、骨骺不规则和生长异常。还对所有入组患者进行了腕骨长度和腰椎骨矿物质密度（全身性骨质疏松症的指标）的调查。实验室检查包括白细胞计数、血小板、C反应蛋白（CRP）、类风湿因子（RF）、抗环瓜氨酸肽（CCP）抗体和基质金属蛋白酶（MMP）-3。 s-JIA和p-JIA实验室检查结果比较表明，p-JIA血清中抗CCP抗体和RF滴度显着升高（P < 0.05）。两组患者的骨密度没有差异。 p-JIA 患者的腕长明显短于 s-JIA 患者（P < 0.05）。 s-JIA 最常见的放射学异常是关节旁骨质减少 (93.8%)，而 p-JIA 的频率为 50.0%。 9.8% 的 s-JIA 患者出现关节间隙狭窄，而 p-JIA 患者的这一比例为 35.7%。 p-JIA 比 s-JIA 更常见软骨下骨囊肿和侵蚀。总之，本研究中 s-JIA 和 p-JIA 的放射学特征和实验室数据存在差异。在放射学评估中，s-JIA 中骨相关异常突出，p-JIA 中关节相关异常显着，这些结果表明这两种 JIA 亚型之间关节炎的致病基础似乎不同。
We performed this study to investigate the differences in radiological and laboratory findings between systemic juvenile idiopathic arthritis (s-JIA) and polyarthritis (p-JIA). Twenty-two patients with s-JIA and 18 with p-JIA were enrolled. Their laboratory findings and radiographs were examined retrospectively. Plain radiographs were obtained before the induction of biological agents. All radiographs were examined for the presence of soft tissue swelling, juxta-articular osteopenia, joint space narrowing, subchondral bone cyst, erosion, epiphyseal irregularity, and growth abnormalities. Carpal length and bone mineral density of the lumbar spine, an indicator of generalized osteoporosis, were also investigated in all the patients enrolled. Laboratory examinations involved white blood cell counts, platelets, C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody, and matrix metalloproteinase (MMP)-3. Comparisons of the laboratory findings between s-JIA and p-JIA indicated that the titers of anti-CCP antibody and RF were significantly increased in p-JIA sera (P < 0.05). There was no difference in BMD between the two groups of patients. Carpal length was significantly shorter in p-JIA patients than in s-JIA patients (P < 0.05). The most frequent radiological abnormality in s-JIA was juxta-articular osteopenia (93.8%), in comparison to a frequency of 50.0% in p-JIA. Joint space narrowing was shown in 9.8% of the s-JIA patients compared to 35.7% of the p-JIA patients. Subchondral bone cyst and erosion were more frequent in p-JIA than s-JIA. In conclusion, there were differences in radiographic characteristics and laboratory data between s-JIA and p-JIA in this study. In the radiological evaluation, bone-related abnormality was prominent in s-JIA and joint-related abnormality was striking in p-JIA, and these results indicated that the pathogenic bases of arthritis appear to differ between these two subtypes of JIA.