RETROSPECTIVE ESTIMATION AND CORRECTION OF PHYSIOLOGICAL FLUCTUATION IN FUNCTIONAL MRI
RETROSPECTIVE ESTIMATION AND CORRECTION OF PHYSIOLOGICAL FLUCTUATION IN FUNCTIONAL MRI
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DOI：
10.1002/mrm.1910340211
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发表时间：
1995-08-01
影响因子：
3.3
通讯作者：
ERHARD, P
中科院分区：
文献类型：
--
作者：
HU, XP;LE, TH;ERHARD, P
由于生理运动引起的图像间波动是功能MRI准确检测神经元活动的主要限制。在本文中，一个新的和一般的技术估计和补偿的生理效应。通过在成像数据的采集期间同时监测呼吸和心跳，并且回顾性地使成像数据与生理活动同步，估计并去除生理效应。该技术不依赖于呼吸或心跳的周期性，不影响由神经元激活引起的信号变化，并且有利于以任何速度获取的图像。用FLASH和EPI序列进行的实验研究表明，新技术能有效地减少生理波动，提高功能磁共振成像的灵敏度，具有普遍适用性。
Image-to-image fluctuation due to physiological motion is a major limitation to the accurate detection of neuronal activity with functional MRI. In this paper, a new and general technique for the estimation and compensation of the physiological effects is presented. By simultaneously monitoring the respiration and heart beat during the acquisition of imaging data, and retrospectively synchronizing the imaging data with physiological activity, physiological effects are estimated and removed. This technique does not rely on the periodicity of the respiration or the heart beat, does not affect the signal changes arising from neuronal activation, and is beneficial to images acquired with any speed. Experimental studies performed with FLASH and EPI sequences have demonstrated that the new technique is effective in reducing physiological fluctuation acid improving the sensitivity of functional MRI and is generally applicable.