Neurocognitive training in patients with high-grade glioma: a pilot study
Neurocognitive training in patients with high-grade glioma: a pilot study
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DOI：
10.1007/s11060-009-0006-2
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发表时间：
2010-03-01
影响因子：
3.9
通讯作者：
Marosi, Christine
中科院分区：
文献类型：
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作者：
Hassler, Marco Ronald;Elandt, Katarzyna;Marosi, Christine
虽然他们的神经认知表现是高级别胶质瘤（HGG）患者的主要问题之一，虽然神经认知缺陷已被描述为与负面的结果，神经认知康复通常不整合到恶性胶质瘤患者的常规护理。在这项试点试验中，每周一次的注意力，语言和记忆技能的小组训练课程提供给HGG患者，训练前和训练后的评估。11名患者，6名患有多形性胶质母细胞瘤，5名患有WHO III级胶质瘤，中位年龄50岁，Karnofsky表现评分为80-100，参加了10次90分钟的团体训练课程。对于基线时和训练后由不参与患者护理或训练的神经心理学家进行的评估，进行了连线测试A和B。采用TMTA和TMTB、霍普金斯言语学习测验（HVLT）和控制性口语词汇联想测验（COWA）。比较基线和12周后训练后评估的平均组间差异，发现所有神经认知变量均有所改善。患者表现出很大的多样性，恶化，改善和稳定。然而，仅在HVLT方面检测到显著的组间差异（基线评分为19.6 +/- 8.9，12周后为23.6 +/- 8.8，P = 0.04）。这项初步研究表明，HGG患者的神经认知训练是可行的，每周一次的团体训练可能能够改善注意力和记忆力。
Although their neurocognitive performance is one of the major concerns of patients with high-grade gliomas (HGG) and although neurocognitive deficits have been described to be associated with negative outcome, neurocognitive rehabilitation is usually not integrated into the routine care of patients with malignant gliomas. In this pilot trial, a weekly group training session for attention, verbal, and memory skills was offered to patients with HGG with pre and post-training evaluation. Eleven patients, six with glioblastoma multiforme and five with WHO grade III gliomas, median age 50 years, with a Karnofsky performance score of 80-100 participated in ten group training sessions of 90 min. For evaluation at baseline and after the training by a neuropsychologist not involved in care or training of the patients, Trail Making Tests A and B (TMTA and TMTB), Hopkins Verbal Learning Test (HVLT), and the Controlled Oral Word Association Test (COWA) were used. Comparison of mean group differences between baseline and at post-training evaluation after 12 weeks revealed improvement across all neurocognitive variables. The patients showed a great diversity in their performances, with worsening, improvement, and stabilization. However, a significant group difference was detected only for the HVLT (score 19.6 +/- 8.9 at baseline, 23.6 +/- 8.8 after 12 weeks, P = 0.04). This pilot study shows that neurocognitive training in patients with HGG is feasible as group training with weekly sessions and might be able to induce improvements in attention and memory skills.