Cut loose and run: The complex role of ADAM proteases during neural crest cell development.
Cut loose and run: The complex role of ADAM proteases during neural crest cell development.
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DOI：
10.1002/dvg.23095
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Taneyhill LA
中科院分区：
文献类型：
--
作者：
Alfandari D;Taneyhill LA
ADAM金属蛋白酶已被证明在发育过程中发挥关键作用。在这篇综述中，我们将描述功能的证据，牵连ADAM蛋白在神经嵴细胞的发生，迁移和分化。我们将我们的分析限制在跨膜的亚当斯，因为其他评论已经解决了细胞外金属蛋白酶的作用。本文将介绍主要通过使用两种脊椎动物模型系统，青蛙和鸟类胚胎已取得的进展。亚当斯的主要底物的作用，钙粘蛋白，已被广泛描述在其他评论，最近在。亚当斯在其他细胞类型（包括免疫系统、伤口愈合和癌症）迁移中的功能先前已在中描述。我们的目标是说明亚当斯在控制神经嵴行为中的重要性，以及神经嵴细胞如何帮助我们了解体内ADAM蛋白的分子相互作用，底物和功能。
ADAM metalloproteases have been shown to play critical roles during development. In this review we will describe functional evidence that implicates ADAM proteins during the genesis, migration and differentiation of neural crest cells. We will restrict our analysis to the transmembrane ADAMs as other reviews have addressed the role of extracellular metalloproteases. This review will describe advances that have been obtained mainly through the use of two vertebrate model systems, the frog and avian embryos. The role of the principal substrates of ADAMs, the cadherins, has been extensively described in other reviews, most recently in. The function of ADAMs in the migration of other cell types, including the immune system, wound healing and cancer has been described previously in. Our goal is to illustrate both the importance of ADAMs in controlling neural crest behavior and how neural crest cells have helped us understand the molecular interactions, substrates and functions of ADAM proteins in vivo.
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4
作者：
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